Department of Animal Science, School of Environmental and Rural Sciences, University of New England, Armidale, NSW 2351, Australia.
Phytobiotics Futterzusatzstoffe GmbH, Wallufer St 10 A, 65343 Eltville, Germany.
Poult Sci. 2017 Oct 1;96(10):3581-3585. doi: 10.3382/ps/pex164.
Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. A standardized blend of plant-derived isoquinoline alkaloids (IQA) derived from Macleaya cordata has shown to have anti-inflammatory potency and promoted animal productivity. This study investigated the effects of IQA supplementation on broiler chickens under NE challenge. A 2 × 2 factorial arrangement of treatments was employed with factors: NE challenge (no or yes), and additives (no additive or IQA at 0.15 g/kg) in starter, grower, and finisher diets. Birds were challenged with Eimeria spp. on d 9 and 108 to 109Clostridium perfringens on d 14. Each treatment had 7 replicate floor pens with 17 birds each. NE challenge negatively affected growth performance, livability, and carcass traits. Regardless of challenge, IQA increased feed intake and gain on d 24 (P < 0.05) and 35 (P < 0.01) and improved FCR (P < 0.05), flock uniformity (P < 0.01) and breast meat yield (P < 0.001) on d 35. Supplementation of IQA also reduced lesions in the duodenum (P < 0.05), jejunum (P < 0.001), and ileum (P < 0.001). This study suggests that IQA may protect broilers from NE indicating its role as a promising antibiotic alternative.
坏死性肠炎（NE）给肉鸡产业造成了巨大的经济损失，尤其是在不使用饲料抗生素的情况下。从博落回中提取的植物源性异喹啉生物碱（IQA）的标准化混合物已显示出具有抗炎效力并促进动物生产性能。本研究调查了 IQA 补充剂在 NE 挑战下对肉鸡的影响。采用 2×2 因子处理设计，因子为：NE 挑战（有或无）和添加剂（无添加剂或在起始、生长和育肥日粮中添加 0.15 g/kg 的 IQA）。在第 9 和 109 天用艾美耳球虫攻毒，在第 14 天用产气荚膜梭菌攻毒。每个处理有 7 个重复的地板笼，每个笼有 17 只鸡。NE 挑战对生长性能、成活率和屠体性状产生负面影响。无论是否受到挑战，IQA 都增加了第 24 天（P < 0.05）和第 35 天（P < 0.01）的采食量和增重，改善了第 35 天的饲料转化率（P < 0.05）、群体均匀度（P < 0.01）和胸肉产量（P < 0.001）。IQA 的补充还减少了十二指肠（P < 0.05）、空肠（P < 0.001）和回肠（P < 0.001）的病变。本研究表明，IQA 可能保护肉鸡免受 NE 的侵害，表明其作为一种有前途的抗生素替代品的作用。
