Olveira Casilda, Padilla Alicia, Dorado Antonio, Contreras Victoria, Garcia-Fuentes Eduardo, Rubio-Martin Elehazara, Porras Nuria, Doña Esperanza, Carmona Ana, Olveira Gabriel
Pneumology Service, IBIMA (Institute of Biomedical Research in Malaga), Regional University of Málaga, Málaga, Spain.
Pneumology Unit, The Costa del Sol Health Agency, Málaga, Spain.
Eurasian J Med. 2017 Jun;49(2):118-123. doi: 10.5152/eurasianjmed.2017.17010.
In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides.
The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls. The following serum and plasma inflammatory and oxidative stress biomarkers were measured: interleukin-6 (IL-6), reactive C protein (RCP), tumor necrosis alpha (TNF-α), glutathione peroxidase (GPx), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD), together with markers of lipid peroxidation (8-isoprostanes and thiobarbituric acid reactive substances [TBARS]). Clinical, anthropometric, lung function, radiological, and analytical variables (albumin, prealbumin, vitamins, and zinc) were also recorded.
We studied 36 adults with CF and 41 controls. No differences were observed in age, gender, or anthropometric variables. The patients had significantly higher levels of IL-6, TNF-α, RCP, TBARS, and isoprostanes, and lower levels of SOD than the controls. Twenty-three of the patients were treated with azithromycin, and they had more severe clinical and radiological parameters than those who were not but nevertheless presented significantly lower levels of TNF-α. No differences were observed in the markers of oxidation.
Inflammation and oxidation biomarkers were increased in patients with CF compared with controls. The use of azithromycin was associated with reduced TNF-α levels and did not influence oxidation parameters.
除了具有抗生素作用外，大环内酯类药物似乎还能调节囊性纤维化（CF）中的炎症反应，并可能影响氧化应激。本研究的目的是评估氧化生物标志物和炎症水平，并确定这些参数与大环内酯类药物摄入量之间是否存在关联。
本横断面研究纳入的受试者，一方面是临床病情稳定的CF患者，另一方面是健康对照者。检测了以下血清和血浆炎症及氧化应激生物标志物：白细胞介素-6（IL-6）、反应性C蛋白（RCP）、肿瘤坏死因子α（TNF-α）、谷胱甘肽过氧化物酶（GPx）、总抗氧化能力（TAC）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD），以及脂质过氧化标志物（8-异前列腺素和硫代巴比妥酸反应性物质[TBARS]）。还记录了临床、人体测量、肺功能、放射学和分析变量（白蛋白、前白蛋白、维生素和锌）。
我们研究了36例成年CF患者和41例对照者。在年龄、性别或人体测量变量方面未观察到差异。与对照者相比，患者的IL-6、TNF-α、RCP、TBARS和异前列腺素水平显著更高，而SOD水平更低。23例患者接受了阿奇霉素治疗，他们的临床和放射学参数比未接受治疗的患者更严重，但TNF-α水平却显著更低。在氧化标志物方面未观察到差异。
与对照者相比，CF患者的炎症和氧化生物标志物升高。阿奇霉素的使用与TNF-α水平降低有关，且不影响氧化参数。
