Center for Synaptic Brain Dysfunctions, Institute for Basic ScienceDaejeon, South Korea.
Neuroscience Graduate Program, Ajou University School of MedicineSuwon, South Korea.
Front Neural Circuits. 2017 Jun 7;11:40. doi: 10.3389/fncir.2017.00040. eCollection 2017.
We have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value- and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regions of rats performing a dynamic foraging task, and chosen value- and reward-related neural activity was estimated using a reinforcement learning model and multiple regression analyses. Neural signals for chosen value and reward converged in both CA3 and CA1 when a trial outcome was revealed. However, these neural signals were stronger in CA1 than CA3. Consequently, neural signals for reward prediction error and updated chosen value were stronger in CA1 than CA3. Together with our previous finding that CA1 conveys stronger value signals than the subiculum, our results raise the possibility that CA1 might play a particularly important role among hippocampal subregions in evaluating experienced events.
我们之前已经表明，CA1 传递了更新所选目标价值所需的重要神经信号，即所选价值和奖励信号。为了更好地理解与估值相关的海马体神经过程，我们比较了 CA3 和 CA1 区域之间的所选价值和奖励相关的神经活动。使用来自执行动态觅食任务的大鼠的四极管在背侧 CA3 和 CA1 区域记录单个单位，并使用强化学习模型和多元回归分析来估计所选价值和奖励相关的神经活动。当揭示试验结果时，所选价值和奖励的神经信号在 CA3 和 CA1 中汇聚。然而，这些神经信号在 CA1 中比 CA3 更强。因此，奖励预测误差和更新的所选值的神经信号在 CA1 中比 CA3 更强。结合我们之前的发现，即 CA1 比下托传递更强的价值信号，我们的结果提出了 CA1 可能在评估经验事件方面在海马体亚区中发挥特别重要作用的可能性。
