Mumcu Gonca, Alibaz-Öner Fatma, Öner Sibel Yılmaz, Özen Gülsen, Atagündüz Pamir, İnanç Nevsun, Köksal Leyla, Ergun Tülin, Direskeneli Haner
Department of Health Management, Marmara University School of Health Sciences, İstanbul, Turkey.
Department of Rheumatology, Marmara University School of Medicine, İstanbul, Turkey.
Eur J Rheumatol. 2017 Jun;4(2):109-112. doi: 10.5152/eurjrheum.2017.160094. Epub 2017 Jun 1.
The aim of this study was to evaluate the relationship between oral ulcer activity and medication adherence according to gender in Behçet's disease (BD) patients.
The study group included 330 BD patients (F/M: 167/163, mean age: 38.5±10.5 years). Oral ulcer activity and medication adherence were evaluated in the previous month. Medication adherence was evaluated using the 8-item Morisky Medication Adherence Scale (MMAS-8) having a score range of "0" to "8" with high scores indicating better adherence. Low adherence was defined as <6 points on MMAS-8.
Over half of the group had active oral ulcers (n=219, 66.4%) within the month preceding the visit. The number of oral ulcers was significantly higher in female patients with low medication adherence (2.39±3.24) than in the rest of the female group (1.28±2.05; p=0.023). Although a similar trend was also observed in male patients (2.14±3.3 vs. 1.81±2.31), a significant relationship was not observed (p=0.89). The frequency of medication intake per day was lower in patients with high medication adherence than in the rest of the study group (p=0.04).
Low medication adherence is a hidden risk factor in the management of BD. Poor adherence was associated with oral ulcer activity in female BD patients.
本研究旨在评估白塞病（BD）患者中口腔溃疡活动与按性别划分的药物依从性之间的关系。
研究组包括330例BD患者（女/男：167/163，平均年龄：38.5±10.5岁）。评估前一个月的口腔溃疡活动和药物依从性。使用8项Morisky药物依从性量表（MMAS-8）评估药物依从性，得分范围为“0”至“8”，高分表示依从性更好。低依从性定义为MMAS-8得分<6分。
超过半数的研究组患者在就诊前一个月内有活动性口腔溃疡（n = 219，66.4%）。药物依从性低的女性患者口腔溃疡数量（2.39±3.24）显著高于其余女性组（1.28±2.05；p = 0.023）。虽然男性患者中也观察到类似趋势（2.14±3.3对1.81±2.31），但未观察到显著相关性（p = 0.89）。药物依从性高的患者每天的服药频率低于研究组其余患者（p = 0.04）。
低药物依从性是BD管理中的一个潜在危险因素。依从性差与女性BD患者的口腔溃疡活动有关。
