Rheumatology and Rehabilitation department, Faculty of Medicine, Cairo University, Kasr Al Ainy St., Cairo, 11562, Egypt.
Clin Rheumatol. 2019 Mar;38(3):761-768. doi: 10.1007/s10067-018-4344-3. Epub 2018 Oct 26.
INTRODUCTION/OBJECTIVES: Despite its importance, adherence to treatment has not been sufficiently studied in Behçet's disease (BD). The aim of this study was to evaluate medication adherence in BD using the Compliance Questionnaire of Rheumatology (CQR) and factors potentially affecting it.
This cross-sectional study included 67 consecutive BD patients including 57 (85%) males with a mean age of 35.1 ± 9.27 years and mean disease duration of 129 ± 91 months. The cumulative clinical manifestations, the Behçet's Disease Current Activity Form (BDCAF) score, and the Vasculitis Damage Index (VDI) were recorded. The CQR, Socioeconomic Status Questionnaire for Health Research in Egypt (SES), the Beliefs about Medication Questionnaire (BMQ), and the Short Form 36 (SF-36) quality of life assessment questionnaire were administered to the patients. Linear regression analysis was done to determine independent predictors of CQR.
The mean BDCAF score was 3.27 ± 3.54 and the VDI was 3.36 ± 2.21. The mean CQR score was 69.2 ± 11.79. The CQR score varied significantly among different health sources (p = 0.02), with no relationship detected with other sociodemographic characteristics, nor with clinical characteristics or the SF-36. Among the investigated medications' complexities, severity of side effects showed significantly different CQR scores (p = 0.004), and a weak positive correlation between medications' numbers and the CQR was detected. Predictors for higher CQR scores included the necessity beliefs score of the BMQ (β = 1.1, p < 0.001); whereas, predictors for lower CQR scores were the harm and concern BMQ subscales ((β = - 1.5, p = 0.004) and (β = - 0.72, p = 0.032), respectively).
Beliefs about medications were the only predictor for adherence in our cohort.
简介/目的：尽管治疗依从性很重要，但在白塞病（BD）中尚未得到充分研究。本研究的目的是使用风湿病依从性问卷（CQR）评估 BD 中的药物依从性，并确定可能影响药物依从性的因素。
本横断面研究纳入了 67 例连续的 BD 患者，包括 57 例（85%）男性，平均年龄为 35.1±9.27 岁，平均病程为 129±91 个月。记录累积临床表现、白塞病活动评分（BDCAF）和血管炎损伤指数（VDI）。向患者发放 CQR、埃及健康研究社会经济状况问卷（SES）、药物信念问卷（BMQ）和健康调查简表 36（SF-36）生活质量评估问卷。进行线性回归分析以确定 CQR 的独立预测因子。
BDCAF 评分的平均值为 3.27±3.54，VDI 为 3.36±2.21。CQR 评分的平均值为 69.2±11.79。不同的健康来源之间 CQR 评分差异显著（p=0.02），但与其他社会人口学特征、临床特征或 SF-36 均无相关性。在所调查的药物复杂性中，副作用严重程度的 CQR 评分差异显著（p=0.004），且药物数量与 CQR 之间存在弱正相关。CQR 评分较高的预测因子包括 BMQ 的必要性信念评分（β=1.1，p<0.001）；而 CQR 评分较低的预测因子包括 BMQ 的危害和担忧亚量表（β=-1.5，p=0.004）和（β=-0.72，p=0.032）。
在本队列中，药物信念是药物依从性的唯一预测因子。
