Liu Xiangchun, Jia Heng, Xia Hongsheng
Orthopedics Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007, China.
Department of Joint Surgery, Chinese Medicine Hospital of the Xinjiang Uygur Autonomous Region, Urumqi 830000.
Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):265-271. doi: 10.21010/ajtcam.v14i4.29. eCollection 2017.
Intra-articular adhesion is the commonest complication that is faced by orthopedic surgeons after knee surgery. Thus, the present investigation evaluates the effect of daidzein on intra-articular adhesion in rabbits.
All the rabbits were separated in to four different groups each group carries ten rabbits. Cancellous bone was exposed in each rabbit by removing cortical bone from both side of the femoral condyle. Following daidzein (2.5, 5 and 10 mg/ml) was topically applied for the duration of 10 min to the decorticated areas. Thereafter for the period of 4 week surgical limb was fixed. Effect of daidzein on intra articular adhesion was estimated by visual score through macroscopic examination, histopathology study, hydroxyproline content, fibroblast and collage density.
Data obtained in the study suggest that topical application of daidzein (5 and 10 mg/ml) loose the collagen and significantly decreases the adhesion at the decorticated areas. Moreover there were significant reduction in the fibroblast density, hydroxyproline content and optical density of collagen tissue in daidzein (5 and 10 mg/ml) treated group than control.
Thus present study concludes that topical application of daidzein reduces intra-articular adhesion around the knee.
关节内粘连是骨科医生在膝关节手术后面临的最常见并发症。因此，本研究评估了大豆苷元对兔关节内粘连的影响。
将所有兔子分为四组，每组十只。通过去除股骨髁两侧的皮质骨，暴露每只兔子的松质骨。随后将大豆苷元（2.5、5和10毫克/毫升）局部应用于去皮质区域10分钟。此后，手术肢体固定4周。通过宏观检查的视觉评分、组织病理学研究、羟脯氨酸含量、成纤维细胞和胶原密度来评估大豆苷元对关节内粘连的影响。
研究获得的数据表明，局部应用大豆苷元（5和10毫克/毫升）可使胶原蛋白松解，并显著降低去皮质区域的粘连。此外，与对照组相比，大豆苷元（5和10毫克/毫升）治疗组的成纤维细胞密度、羟脯氨酸含量和胶原组织光密度均显著降低。
因此，本研究得出结论，局部应用大豆苷元可减少膝关节周围的关节内粘连。
