Hagmann Stefan H F
Division of Pediatric Infectious Diseases, Steven and Alexandra Cohen Children's Medical Center, Northwell Health, 269-01 76th Avenue, New Hyde Park, NY, 11040, USA.
Curr Infect Dis Rep. 2017 Aug;19(8):29. doi: 10.1007/s11908-017-0584-7.
While the Zika virus (ZIKV) has been noted for its distinct neurotropism and identified as a significant cause for a congenital infection syndrome, there has been increased recognition of the importance to better understand the clinical impact of non-congenital ZIKV infection in infants and children. This article reviews reports of perinatal and breast milk transmission of ZIKV and summarizes current clinical outcome data of pediatric non-congenital ZIKV infection.
Perinatal transmission and presence of infective ZIKV particles in breast milk have been reported. Most symptomatic non-congenital ZIKV infection in infants and children is mild and self-limited, but long-term follow-up studies are lacking. The mechanism and impact of perinatal and breast milk transmission is unclear. The current WHO infant feeding guidelines in areas of ZIKV transmission support breastfeeding. Unless any scientific data raise concern regarding transmission via breastfeeding, the current guidelines should continue to be followed. Prospective population-based cohort studies to investigate maternal, perinatal, infant, and child outcomes are needed.
虽然寨卡病毒（ZIKV）因其独特的嗜神经性而受到关注，并被确定为先天性感染综合征的一个重要病因，但人们越来越认识到更好地了解寨卡病毒非先天性感染对婴幼儿临床影响的重要性。本文回顾了寨卡病毒围产期传播及母乳传播的报告，并总结了儿童非先天性寨卡病毒感染的当前临床结局数据。
已有围产期传播及母乳中存在感染性寨卡病毒颗粒的报告。婴幼儿中大多数有症状的非先天性寨卡病毒感染症状轻微且为自限性，但缺乏长期随访研究。围产期传播及母乳传播的机制和影响尚不清楚。世界卫生组织在寨卡病毒传播地区的现行婴儿喂养指南支持母乳喂养。除非有任何科学数据引发对母乳喂养传播的担忧，否则应继续遵循现行指南。需要开展基于人群的前瞻性队列研究以调查母亲、围产期、婴儿及儿童的结局。
