Matsuda Yoko, Tanaka Masashi, Sawabe Motoji, Mori Seijiro, Muramatsu Masaaki, Mieno Makiko Naka, Furukawa Toru, Arai Tomio
Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Genes Chromosomes Cancer. 2018 Jan;57(1):12-18. doi: 10.1002/gcc.22479. Epub 2017 Oct 31.
We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN-1, -2, -3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.
我们基于胰腺病变、临床信息和单核苷酸多态性（SNP），对2205例日本老年胰腺上皮内瘤变（PanIN）和胰腺导管腺癌（PDAC）患者的系列尸检结果进行了比较分析。这些患者中PanIN-1、-2、-3和PDAC的发生率分别为55%、12%、1.4%和2.4%。PanIN的发生与女性、年龄增长和较低的体重指数相关。我们未在PanIN和PDAC之间鉴定出任何常见的SNP。男性和女性的PanIN与PDAC之间均不存在共同的SNP。在先前报道的胰腺癌相关SNP中，rs3790844（NR5A2）在我们的队列中与PDAC显示出显著相关性。6个与血脂水平相关的SNP（rs7016880、rs10096633、rs10503669、rs12678919、rs17482753、rs328）与PDAC风险相关。我们的数据表明，不同的临床病理特征和易感性可能影响日本老年患者的胰腺癌发生。
