评价 2014 年中国广州登革热疫情期间献血者中无症状登革热感染情况。
An evaluation of asymptomatic Dengue infections among blood donors during the 2014 Dengue outbreak in Guangzhou, China.
机构信息
Guangzhou Blood Center, Guangzhou, Guangdong, China.
Department of Transfusion Medicine, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
出版信息
J Med Virol. 2017 Nov;89(11):2037-2040. doi: 10.1002/jmv.24883. Epub 2017 Jul 20.
In 2014, an outbreak of dengue virus (DENV) infection led to 45 171 clinical cases diagnosed in Guangdong province, Southern China. However, the potential risk of blood donors asymptomatically infected with DENV has not been evaluated . In the current study we detected anti-DENV IgG antibody and RNA in volunteer Chinese blood donors. We found that anti-DENV IgG antibody was positively detected in 3.4% (51/1500) and two donors were detected as being DENV RNA positive out of 3000 blood samples. We concluded that the presence of potential DENV in blood donors might be potential risk for blood safety. Therefore, screening for DENV infection should be considered in blood donations during a period of dengue outbreak in high epidemic area of China.
2014 年，中国南方广东省爆发登革热病毒（DENV）感染，导致确诊临床病例 45171 例。然而，无症状感染 DENV 的献血者的潜在风险尚未得到评估。在本研究中，我们检测了中国志愿献血者的抗 DENV IgG 抗体和 RNA。我们发现，在 1500 份血样中，抗 DENV IgG 抗体呈阳性的比例为 3.4%（51/1500），在 3000 份血样中，有 2 份血样检测到 DENV RNA 呈阳性。我们的结论是，献血者中存在潜在的 DENV 可能是血液安全的潜在风险。因此，在中国登革热高发地区，在登革热流行期间，应该考虑对献血者进行 DENV 感染筛查。
Zotero 插件