Chen Haifeng, Zhai Cai, Zhang Huabing, Zhu Chen, Rueping Magnus
KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Ningbo Institute of Digital Twin, Eastern Institute of Technology, Ningbo, China.
Nat Commun. 2025 Aug 6;16(1):7247. doi: 10.1038/s41467-025-62141-x.
The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method for the construction of alkyl germanes, utilizing a variety of functionalized alkyl nitriles and commercially available chlorogermanes. The developed decyanative germylation approach allows for the efficient and modular preparation of a wide range of structurally diverse alkyl germanes under mild reaction conditions. Notably, primary, secondary, and tertiary alkyl nitriles are all compatible. Furthermore, a series of natural product and drug-derived substrates undergo smooth late-stage functionalization, yielding the corresponding complex alkyl germanes.
由于烷基锗在影响人类生活质量的各个领域中发挥着重要作用，因此开发高效通用的构建烷基锗的策略至关重要。在此，我们报告了一种强大的电化学驱动方法来构建烷基锗，该方法利用各种功能化烷基腈和市售氯锗烷。所开发的脱氰基锗化方法能够在温和的反应条件下高效、模块化地制备各种结构多样的烷基锗。值得注意的是，伯、仲和叔烷基腈均适用。此外，一系列天然产物和药物衍生的底物能够顺利地进行后期功能化，生成相应的复杂烷基锗。
