肿瘤坏死因子-α -308G/A基因多态性与头颈癌风险无关联：一项遵循PRISMA标准的荟萃分析。
No association of TNF-α-308G/A polymorphisms with head and neck cancer risk: A PRISMA-compliant meta-analysis.
作者信息
Yuan Cheng, Xu Xin-Hua, Xu Lu, Liu Yang, Sun Min, Ni Li-Hua, Wang Xiao-Long, Chen Zhuo, Zhang Kun, Zeng Guang
机构信息
The First College of Clinical Medical Science, China Three Gorges University Department of Oncology, Yichang Central People's Hospital, Yichang Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan Zhongda Hospital, Southeast University, Nanjing, China Klinikum rechts der Isar Technical University of Munich, München, Germany Biomedical Engineering, Stony Brook University, Stony Brook, NY.
出版信息
Medicine (Baltimore). 2017 Jun;96(25):e7298. doi: 10.1097/MD.0000000000007298.
BACKGROUND
A number of studies had reported the association between tumor necrosis factor-alpha (TNF-α) gene polymorphisms and head and neck cancer (HNC) risk. However, the results remained controversial. Therefore, we performed a meta-analysis to derive a more precise evaluation of the association between TNF-α-308G/A polymorphism and overall HNC risk and evaluated influence of cancer types and ethnicities.
METHODS
A systematic literature search was performed using Pubmed, Embase, Cochrane Library, and Web of science. In total, we identified 15 studies including 2005 cancer cases and 2876 controls to evaluate the association of TNF-α-308G/A polymorphism with risk for HNC.
RESULTS
Overall, there was no significant association between TNF-α-308G/A polymorphism and the risk of HNC. Furthermore, subgroup analyses were performed according to the types of tumor and the ethnicities, we also found there was no significant association between TNF-α-308G/A polymorphism and the risk of NPC and OC, and European and Asian populations had no statistically significant difference in the relationship of TNF-α-308G/A polymorphism and HNC susceptibility.
CONCLUSION
This meta-analysis indicates that the TNF-α-308G/A polymorphism is not associated with HNC risk. In the future, large and well-designed case-control studies are needed to validate our findings.
背景
多项研究报道了肿瘤坏死因子-α（TNF-α）基因多态性与头颈癌（HNC）风险之间的关联。然而，结果仍存在争议。因此，我们进行了一项荟萃分析，以更精确地评估TNF-α -308G/A多态性与总体HNC风险之间的关联，并评估癌症类型和种族的影响。
方法
使用PubMed、Embase、Cochrane图书馆和科学网进行系统的文献检索。我们总共确定了15项研究，包括2005例癌症病例和2876例对照，以评估TNF-α -308G/A多态性与HNC风险的关联。
结果
总体而言，TNF-α -308G/A多态性与HNC风险之间无显著关联。此外，根据肿瘤类型和种族进行亚组分析，我们还发现TNF-α -308G/A多态性与鼻咽癌（NPC）和口腔癌（OC）风险之间无显著关联，并且欧洲和亚洲人群在TNF-α -308G/A多态性与HNC易感性的关系上无统计学显著差异。
结论
这项荟萃分析表明，TNF-α -308G/A多态性与HNC风险无关。未来，需要进行大规模且设计良好的病例对照研究来验证我们的发现。
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