Munetz M R, Roth L H
Arch Gen Psychiatry. 1985 Sep;42(9):866-71. doi: 10.1001/archpsyc.1985.01790320034005.
The effects of a formal (written) approach v an informal (oral) approach to obtaining informed consent for neuroleptic treatment were compared in 25 schizophrenic outpatients with tardive dyskinesia. Both groups had significant increases in knowledge, but only the informal/oral presentation group retained significant new knowledge at two-month follow-up. Overall, patients did not learn the information deemed most relevant for rational decision making about neuroleptic treatment. Younger patients started out with more knowledge and retained significant new knowledge at follow-up. All study patients remained in treatment and all but one remained on neuroleptic regimens. There was no increase in relapse or treatment noncompliance in the study population compared with a comparison group. While information about tardive dyskinesia can be safely disclosed to schizophrenic outpatients, such disclosure is evidently most meaningful when repeated informally in the context of a therapeutic relationship.
在25名患有迟发性运动障碍的精神分裂症门诊患者中，比较了采用正式（书面）方式与非正式（口头）方式获取抗精神病药物治疗知情同意书的效果。两组患者的知识水平均有显著提高，但只有非正式/口头陈述组在两个月的随访中仍保留了显著的新知识。总体而言，患者并未掌握被认为对关于抗精神病药物治疗的合理决策最为相关的信息。较年轻的患者一开始知识水平较高，且在随访中保留了显著的新知识。所有研究患者均继续接受治疗，除一人外，其余所有人仍维持抗精神病药物治疗方案。与对照组相比，研究人群中的复发率或治疗不依从率并未增加。虽然可以将有关迟发性运动障碍的信息安全地告知精神分裂症门诊患者，但在治疗关系的背景下进行非正式的反复告知时，这种披露显然最有意义。
