L-643.441：一种对人体有强效且持久作用的H2受体拮抗剂。
L-643.441: an H2-receptor antagonist with potent and long-lasting effects in man.
作者信息
Henry D A, Somerville K W, Kitchingman G K, Holmes I B, Tobert J A, Langman M J
出版信息
Br J Clin Pharmacol. 1985 Aug;20(2):133-6. doi: 10.1111/j.1365-2125.1985.tb05043.x.
Abstract
Submaximal dose pentagastrin tests conducted in normal male volunteers with L-643.441, a novel histamine H2-receptor antagonist, indicate that it is a potent and long-acting inhibitor of gastric acid secretion. The effect appears dose-dependent and single doses of 50 mg are sufficient to reduce secretory potential by at least 50% when examined 24 h after drug administration. No adverse effects attributable to treatment were observed.
摘要
在正常男性志愿者中使用新型组胺H2受体拮抗剂L-643.441进行的次最大剂量五肽胃泌素试验表明，它是一种强效且长效的胃酸分泌抑制剂。这种作用呈剂量依赖性，给药24小时后进行检测时，50毫克的单次剂量足以使分泌潜能降低至少50%。未观察到与治疗相关的不良反应。
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本文引用的文献
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The stability of gastric acid secretion during prolonged pentagastrin stimulation in man.人在长时间五肽胃泌素刺激过程中胃酸分泌的稳定性。
Clin Sci (Lond). 1984 Jan;66(1):99-101. doi: 10.1042/cs0660099.
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Apparent irreversible H2-receptor blocking and prolonged gastric antisecretory activities of 3-N-(3-[3-(1-piperidinomethyl)phenoxy]propyl) amino-4-amino-1,2,5-thiadiazole-1-oxide (L-643, 441).3-N-(3-[3-(1-哌啶甲基)苯氧基]丙基)氨基-4-氨基-1,2,5-噻二唑-1-氧化物（L-643,441）明显的不可逆H2受体阻断作用及延长的胃抗分泌活性
J Pharmacol Exp Ther. 1983 Mar;224(3):514-9.
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Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies.使用惰性标记物（酚红）提高胃液分泌研究的准确性。
Gut. 1969 Oct;10(10):787-95. doi: 10.1136/gut.10.10.787.
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