Fry Anna, Littlejohns Thomas J, Sudlow Cathie, Doherty Nicola, Adamska Ligia, Sprosen Tim, Collins Rory, Allen Naomi E
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034. doi: 10.1093/aje/kwx246.
The UK Biobank cohort is a population-based cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010. Approximately 9.2 million individuals aged 40-69 years who lived within 25 miles (40 km) of one of 22 assessment centers in England, Wales, and Scotland were invited to enter the cohort, and 5.5% participated in the baseline assessment. The representativeness of the UK Biobank cohort was investigated by comparing demographic characteristics between nonresponders and responders. Sociodemographic, physical, lifestyle, and health-related characteristics of the cohort were compared with nationally representative data sources. UK Biobank participants were more likely to be older, to be female, and to live in less socioeconomically deprived areas than nonparticipants. Compared with the general population, participants were less likely to be obese, to smoke, and to drink alcohol on a daily basis and had fewer self-reported health conditions. At age 70-74 years, rates of all-cause mortality and total cancer incidence were 46.2% and 11.8% lower, respectively, in men and 55.5% and 18.1% lower, respectively, in women than in the general population of the same age. UK Biobank is not representative of the sampling population; there is evidence of a "healthy volunteer" selection bias. Nonetheless, valid assessment of exposure-disease relationships may be widely generalizable and does not require participants to be representative of the population at large.
英国生物银行队列是一个基于人群的队列，由2006年至2010年期间在英国招募的50万名参与者组成。在英格兰、威尔士和苏格兰的22个评估中心之一方圆25英里（40公里）内居住的约920万40 - 69岁个体被邀请加入该队列，5.5%的人参加了基线评估。通过比较未参与者和参与者的人口统计学特征，对英国生物银行队列的代表性进行了调查。将该队列的社会人口学、身体、生活方式和健康相关特征与全国代表性数据源进行了比较。与未参与者相比，英国生物银行的参与者年龄更大、女性更多，且生活在社会经济剥夺程度较低的地区。与一般人群相比，参与者肥胖、吸烟和每日饮酒的可能性较小，自我报告的健康状况也较少。在70 - 74岁时，男性的全因死亡率和总癌症发病率分别比同年龄的一般人群低46.2%和11.8%，女性分别低55.5%和18.1%。英国生物银行并不代表抽样人群；有证据表明存在“健康志愿者”选择偏差。尽管如此，对暴露 - 疾病关系的有效评估可能具有广泛的普遍性，并且不要求参与者代表整个总体人群。
