Wu Chi-Shin, Hsu Le-Yin, Shen Chen-Yang, Chen Wei J, Lin Mei-Chen, Fan Chun Chieh, Wang Shi-Heng
National Center for Geriatrics and Welfare Research, National Health Research Institutes.
Department of Psychiatry, National Taiwan University Hospital, Yunlin Branch.
J Epidemiol. 2025 Apr 5;35(4):206-211. doi: 10.2188/jea.JE20240297. Epub 2025 Feb 28.
This study investigated fundamental demographic variables within the Taiwan Biobank (TWBB) and compared them with national demographic statistics. Additionally, a matched cohort analysis compared TWBB participants with nonparticipants to uncover disparities in sociodemographic and clinical characteristics.
A total of 128,663 individuals aged 30 to 70 years without cancer were recruited within the TWBB, and 514,652 nonparticipants matched by age and sex were randomly selected from the National Health Insurance claims database. Sociodemographic variables, healthcare utilization metrics, underlying medical conditions, and subsequent mortality and cancer risk were analyzed.
TWBB participants were more likely to be female, older, married, higher educated, with higher incomes, and urban residency. Healthcare utilization metrics showed minimal differences. Pre-cohort entry, TWBB participants had a higher prevalence of certain medical conditions, such as peptic ulcer disease, osteoarthritis, osteoporosis, and uterine leiomyoma in females. During follow-up periods, elevated mortality rates were observed among TWBB participants but decreased cancer risk.
The TWBB cohort exhibits disparities in sociodemographic and health-related attributes compared to the general population, comprising participants who were older, female, married, higher educated, higher income, and predominantly resided in urban areas. While mortality rates are slightly elevated within the TWBB cohort, cancer incidence rates are lower. Despite limitations in representativeness, the TWBB's size and exposure measures offer valuable insights into associations between exposures and health conditions.
本研究调查了台湾生物银行（TWBB）内的基本人口统计学变量，并将其与全国人口统计数据进行比较。此外，一项匹配队列分析比较了TWBB参与者与非参与者，以发现社会人口统计学和临床特征方面的差异。
在TWBB中招募了总共128,663名年龄在30至70岁之间且无癌症的个体，并从国民健康保险索赔数据库中随机选择了514,652名按年龄和性别匹配的非参与者。分析了社会人口统计学变量、医疗保健利用指标、潜在医疗状况以及随后的死亡率和癌症风险。
TWBB参与者更有可能是女性、年龄较大、已婚、受教育程度较高、收入较高且居住在城市。医疗保健利用指标显示差异极小。在队列进入前，TWBB参与者某些疾病的患病率较高，如消化性溃疡疾病、骨关节炎、骨质疏松症以及女性的子宫平滑肌瘤。在随访期间，观察到TWBB参与者的死亡率升高，但癌症风险降低。
与一般人群相比，TWBB队列在社会人口统计学和健康相关属性方面存在差异，包括年龄较大、女性、已婚、受教育程度较高、收入较高且主要居住在城市地区的参与者。虽然TWBB队列中的死亡率略有升高，但癌症发病率较低。尽管在代表性方面存在局限性，但TWBB的规模和暴露测量为暴露与健康状况之间的关联提供了有价值的见解。
