Yoshimura M, Kida H, Saito Y, Yokoyama H, Tomosugi N, Abe T, Hattori N
Clin Nephrol. 1985 Sep;24(3):120-7.
Seventeen kidney specimens (6 biopsies and 11 autopsies) of Takayasu's arteritis disclosed two types of glomerular lesions. One was a mild axial mesangial proliferation associated with intramembranous and mesangial electron dense deposits consisting of IgG, IgM and C3 (axial type). The other was a centrolobular mesangial thickening associated with a hyaline deposition showing a mosaic pattern ("centrolobular mesangiopathy": centrolobular type). Mesangiolytic lesions, nodulous lesions, microaneurysms in glomeruli and extensive deposition of hyaline materials both in afferent and efferent arterioles were also observed. The former lesion was found in 4 patients with an active arteritis; and the latter was mainly observed in autopsy cases having a long-term clinical course. In the genesis of the axial type, immune complex deposition caused by the active aortitis may be involved, while the glomerular ischemia caused by the vascular lesions may be implicated in the development of the centrolobular type.
17例大动脉炎肾标本（6例活检和11例尸检）显示出两种类型的肾小球病变。一种是轻度的轴性系膜增生，伴有由IgG、IgM和C3组成的膜内及系膜电子致密沉积物（轴性类型）。另一种是小叶中心系膜增厚，伴有呈镶嵌样图案的透明样沉积（“小叶中心系膜病”：小叶中心型）。还观察到肾小球的系膜溶解病变、结节状病变、微动脉瘤以及入球和出球小动脉中广泛的透明样物质沉积。前一种病变见于4例活动性动脉炎患者；后一种主要在有长期临床病程的尸检病例中观察到。在轴性类型的发生中，可能涉及活动性主动脉炎引起的免疫复合物沉积，而血管病变导致的肾小球缺血可能与小叶中心型的发展有关。
