Department of Medical Chemistry, Medical University of Gdansk, Poland.
College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Chem Biol Interact. 2018 Nov 1;295:38-51. doi: 10.1016/j.cbi.2017.06.018. Epub 2017 Jun 19.
Nanotechnology is a rapidly developing branch of science, which studies control of phenomena and materials sized below 100 nm. Nanotechnology is applicable in many areas of life and medicine including skin care and personal hygiene. The nanoparticles (NPs) of metals and metal oxides are increasingly used in dermatology and cosmetology, especially in prevention and treatment of bacterial and fungal infections, in protection against the harmful effects of the sun and in preparations reducing the visibility of scars by accelerating the repair processes of skin cells. NPs may also be used for skin care and dermatological treatments to improve the quality of life of patients. Nanodermatology and nanocosmetology offer effective, safe, fast-acting product formulations, thus minimizing the side effects of the products used so far. The unique properties of NPs: high surface area relative to the size as well as the ability to penetrate biological membranes and barriers greatly reduces systemic dose thus potential side effects and toxicity. Recent studies show very promising clinical potential of NPs to serve as controlled release and delivery systems for drugs/active substances. In addition, NPs can be used in diagnostic imaging of skin diseases. However, NPs may also carry a risk of cytotoxicity and side effects. The present review focuses on the use of metal and metal oxide NPs in dermatology and cosmetology and their interactions with skin cells.
纳米技术是一门快速发展的科学分支，研究的是对尺寸小于 100nm 的现象和材料的控制。纳米技术在包括皮肤护理和个人卫生在内的许多生活和医学领域都有应用。金属和金属氧化物的纳米颗粒（NPs）越来越多地用于皮肤病学和化妆品学，特别是在预防和治疗细菌和真菌感染、防止太阳有害影响以及通过加速皮肤细胞修复过程减少疤痕可见度的制剂中。NPs 也可用于皮肤护理和皮肤病治疗，以改善患者的生活质量。纳米皮肤病学和纳米化妆品学提供了有效、安全、快速作用的产品配方，从而最大限度地减少了迄今为止使用的产品的副作用。NPs 的独特性质：高表面积与尺寸的比值以及穿透生物膜和屏障的能力，大大降低了全身剂量，从而降低了潜在的副作用和毒性。最近的研究表明，NPs 作为药物/活性物质的控释和传递系统具有非常有前景的临床潜力。此外，NPs 可用于皮肤疾病的诊断成像。然而，NPs 也可能带来细胞毒性和副作用的风险。本综述重点介绍了金属和金属氧化物 NPs 在皮肤病学和化妆品学中的应用及其与皮肤细胞的相互作用。
