Crystal Growth Centre, Anna University, Chennai 600025, India.
Division of Microbiology, Entomology Research Institute, Loyola College, Chennai 600034, India.
IET Nanobiotechnol. 2014 Jun;8(2):111-7. doi: 10.1049/iet-nbt.2012.0008.
Antibacterial and antifungal activities of zinc oxide nanoparticles (ZnO NPs) were investigated against infectious microorganisms. ZnO NPs were prepared by wet chemical precipitation method varying the pH values. Particle size and morphology of the as-prepared ZnO powders were characterised by X-ray diffraction, Fourier transform infrared spectroscopy and transmission electron microscope. The zone of inhibition by NPs ranged from 0 to 17 mm. The lowest minimum inhibitory concentration value of NPs is 25 µg.ml(-1) against Staphylococcus epidermidis. These studies demonstrate that ZnO NPs have wide range of antimicrobial activities towards various microorganisms. The results obtained in the authors' study indicate that the inhibitory efficacy of ZnO NPs is significantly dependent on its chosen concentration and size. Significant inhibition in antibacterial response was observed for S. epidermidis when compared with control antibiotic.
氧化锌纳米粒子（ZnO NPs）的抗菌和抗真菌活性已针对感染性微生物进行了研究。通过湿法化学沉淀法制备 ZnO NPs，改变 pH 值。通过 X 射线衍射、傅里叶变换红外光谱和透射电子显微镜对所制备的 ZnO 粉末的粒径和形态进行了表征。纳米粒子的抑菌圈范围为 0 至 17 毫米。纳米粒子对表皮葡萄球菌的最低最小抑菌浓度值为 25μg.ml(-1)。这些研究表明，氧化锌纳米粒子对各种微生物具有广泛的抗菌活性。作者研究中的结果表明，氧化锌纳米粒子的抑制效果与其选择的浓度和尺寸显著相关。与对照抗生素相比，表皮葡萄球菌的抗菌反应受到显著抑制。
