Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
Clin Neurophysiol. 2018 May;129(5):1001-1010. doi: 10.1016/j.clinph.2018.01.075. Epub 2018 Feb 27.
This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency.
Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated.
Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands.
Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation.
Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection.
本研究旨在利用直接从深部脑刺激（DBS）电极记录的活动，解决不同频率的局部场电位（LFP）活动的聚焦性和独特性。
对接受丘脑底核 DBS 治疗的帕金森病（PD）患者进行术前和术中磁共振成像（MRI）采集，并在静息和提示运动时进行术中 LFP 记录。使用 Lead-DBS®工具包重建和 3D 可视化图像，以确定触点的坐标。估计 LFP 振荡的静息频谱功率和运动相关的功率调制。
在静息状态下记录的丘脑底核 LFP 活动及其对运动的调制在 alpha、beta 和 gamma 波段都有明显的最大值。alpha 波段活动的空间分布及其调制与 beta 波段明显不同。此外，在不同频段的运动相关调制的幅度和时间上都有显著差异。
通过空间拓扑和运动相关调制的模式，可以区分特定频带内的丘脑底核 LFP 活动。
评估丘脑底核 LFPs 的运动相关调制的频率、聚焦性和模式揭示了该区域神经群体活动的异质性。这可能有助于优化术中靶点定位和术后触点选择。
