Deng Heng, Wang Jian Min, Li Ming, Tang Ran, Tang Kun, Su Yingzi, Hou Yong, Zhang Jun
1 Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, China.
2 Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.
Tumour Biol. 2017 Jun;39(6):1010428317706332. doi: 10.1177/1010428317706332.
Dysregulation of long non-coding RNAs has been found in many human cancers, including colorectal cancer that is still the third most prevalent cancer worldwide and related to poor prognosis; along with this, robust testimony has identified that long non-coding RNAs can take charge of tumor suppressor genes or oncogenes. This review summarizes nowadays research achievements on the character of long non-coding RNAs in the prognosis and diagnosis of colorectal cancer. On the basis of the results acquired in the last decade, some long non-coding RNAs are rising as biomarkers of colorectal cancer for prognosis, diagnosis, even prediction of therapeutic result, and have crucial effects in the regulation of colorectal cancer cell functions such as proliferation, invasion, apoptosis, metastasis, and drug resistant ability. Also, long non-coding RNAs, circulating in body fluids, could act as novel, affordable, lightly accessible, non-invasive detection tools for the personal health management of patients with colorectal cancer. Especially, circulating long non-coding RNA profiles may be demonstrating preferable prognostic and diagnostic capability and better accuracy than respective long non-coding RNAs in colorectal cancer.
在许多人类癌症中都发现了长链非编码RNA的失调，包括结直肠癌，它仍是全球第三大常见癌症且预后较差；与此同时，有力证据表明长链非编码RNA可以调控肿瘤抑制基因或癌基因。本综述总结了目前关于长链非编码RNA在结直肠癌预后和诊断方面特性的研究成果。基于过去十年所取得的结果，一些长链非编码RNA正逐渐成为结直肠癌预后、诊断甚至治疗效果预测的生物标志物，并在调控结直肠癌细胞功能（如增殖、侵袭、凋亡、转移和耐药能力）方面发挥关键作用。此外，在体液中循环的长链非编码RNA可以作为新型、经济实惠、易于获取的非侵入性检测工具，用于结直肠癌患者的个人健康管理。特别是，循环长链非编码RNA谱在结直肠癌中可能比单个长链非编码RNA表现出更好的预后和诊断能力及更高的准确性。
