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长链非编码 RNA TUG1 与 TGF-β/P53 表达在结直肠癌中的相互作用。

Interplay of LncRNA TUG1 and TGF-β/P53 Expression in Colorectal Cancer.

机构信息

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt.

Pathology Department, Faculty of Medicine, Zagazig University, Egypt.

出版信息

Asian Pac J Cancer Prev. 2023 Nov 1;24(11):3957-3968. doi: 10.31557/APJCP.2023.24.11.3957.

DOI:10.31557/APJCP.2023.24.11.3957
PMID:38019256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10772770/
Abstract

BACKGROUND

Colorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide. It is still necessary to further define the mechanisms and explore the therapeutic targets of CRC. Long non-coding RNA taurine upregulated gene 1 (LncRNA TUG1) was initially discovered as a transcript upregulated by taurine and is observed to be expressed in numerous human cancers. The Study Aim: This article was to explore the correlation between transforming growth factor-beta (TGF-β)/tumor protein 53 (P53) signaling mechanisms as regulators for LncRNA TUG1 in Egyptian patients with CRC.

SUBJECTS AND METHODS

Immunohistochemical (IHC) staining was achieved to study TGF-β and P53 expression in CRC specimens vs. normal colonic specimens and quantitative real-time PCR (qRT-PCR) was used to analyze LncRNA TUG1, TGF-β, and P53 relative gene expression in 96 tissue specimens (neoplastic specimens and the corresponding adjacent non-neoplastic specimens).

RESULTS

The expressions of LncRNA TUG1, TGF-β, and P53 were overexpressed significantly in CRC specimens as opposed to the matched neighboring non-neoplastic specimens (P<0.001), also LncRNA TUG1 was significantly positively correlated to the expression of TGF-β and P53 (r=0.89, 0.91 respectively, P<0.001).

CONCLUSION

These findings reveal that LncRNA TUG1 may be a molecular component in the TGF-β/P53 signaling pathway, and LncRNA TUG1 could function as a CRC possible oncogene. LncRNA TUG1 may serve as a potential oncogene for CRC. The TGF-β/P53/LncRNA TUG1 interactions may be employed as potential targets for CRC diagnosis, prognostic evaluation, and cure.

摘要

背景

结直肠癌（CRC）是全球最常见和最致命的癌症之一。仍有必要进一步明确其机制并探索 CRC 的治疗靶点。长链非编码 RNA 牛磺酸上调基因 1（LncRNA TUG1）最初被发现是一种受牛磺酸上调的转录本，在许多人类癌症中均有表达。研究目的：本文旨在探讨转化生长因子-β（TGF-β）/肿瘤蛋白 53（P53）信号机制作为调节埃及 CRC 患者 LncRNA TUG1 的相关性。

受试者和方法

免疫组织化学（IHC）染色用于研究 CRC 标本与正常结肠标本中 TGF-β 和 P53 的表达，并使用实时定量 PCR（qRT-PCR）分析 96 个组织标本（肿瘤标本和相应的相邻非肿瘤标本）中 LncRNA TUG1、TGF-β 和 P53 的相对基因表达。

结果

LncRNA TUG1、TGF-β 和 P53 的表达在 CRC 标本中明显高于匹配的相邻非肿瘤标本（P<0.001），并且 LncRNA TUG1 与 TGF-β 和 P53 的表达呈显著正相关（r=0.89，0.91，P<0.001）。

结论

这些发现表明 LncRNA TUG1 可能是 TGF-β/P53 信号通路中的一个分子组成部分，LncRNA TUG1 可能作为 CRC 的潜在癌基因。LncRNA TUG1 可能作为 CRC 的潜在癌基因。TGF-β/P53/LncRNA TUG1 相互作用可能作为 CRC 诊断、预后评估和治疗的潜在靶点。

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