Christiansen C, Riis B J, Nilas L, Rødbro P, Deftos L
Lancet. 1985 Oct 12;2(8459):800-1. doi: 10.1016/s0140-6736(85)90794-9.
10 healthy early postmenopausal women were treated with oestrogen and progestagen for two cycles of 28 days. Serum alkaline phosphatase and bone Gla protein increased during progestagen administration, whereas urinary excretion of calcium and hydroxyproline fell significantly during treatment, independently of progestagen intake. Thus, bone formation increases when progestagen is added to oestrogen treatment, whereas bone resorption may be kept constantly low during oestrogen plus progestagen treatment, leading to a positive calcium balance. This makes possible effective treatment of postmenopausal osteoporosis--treatment of elderly postmenopausal women with substantial bone loss before their bones have fractured or when they have just started to fracture. This study design can be used for easy and rapid screening of potential drugs for the prevention and treatment of postmenopausal bone loss.
10名健康的绝经早期妇女接受了雌激素和孕激素治疗，为期两个28天的周期。在孕激素给药期间，血清碱性磷酸酶和骨钙素增加，而在治疗期间，尿钙和羟脯氨酸排泄显著下降，与孕激素摄入量无关。因此，在雌激素治疗中添加孕激素时骨形成增加，而在雌激素加孕激素治疗期间骨吸收可能持续保持在低水平，导致钙平衡为正。这使得有效治疗绝经后骨质疏松症成为可能——治疗骨质大量流失的老年绝经后妇女，在她们的骨骼骨折之前或刚开始骨折时。这种研究设计可用于简便快速地筛选预防和治疗绝经后骨质流失的潜在药物。
