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Differentiation of osteoblast in vitro is regulated by progesterone.

作者信息

Chen L, Foged N T

机构信息

Department of Endocrinology, Xiehe Hospital, Tongji Medical University, Wuhan.

出版信息

J Tongji Med Univ. 1996;16(2):83-6. doi: 10.1007/BF02887963.

DOI:10.1007/BF02887963
PMID:9275698
Abstract

The regulation of cellular differentiation by progesterone in fetal rat calvarial osteoblasts was investigated. Our results showed that cells cultured in the presence of progesterone had a 7% increase in the alkaline phosphatase activity when compared to untreated cells. The concentration of osteocalcin in the conditioned medium from progesterone treated osteoblasts was 28% higher than that of untreated controls. In addition, administration of progesterone significantly enhanced the number and area of bone nodules. In conclusion, progesterone stimulates the differentiation of fetal rat calvarial osteoblastic cells in vitro.

摘要

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引用本文的文献

1
Induction of osteocalcin gene expression in vitro by progesterone.孕酮在体外诱导骨钙素基因表达。
J Tongji Med Univ. 1997;17(2):72-4. doi: 10.1007/BF02888237.

本文引用的文献

1
ALP induction by beta-glycerophosphate during the non-mineralization phase in vitro.
J Tongji Med Univ. 1996;16(1):20-4. doi: 10.1007/BF02889038.
2
Prevention of bone mineral loss in postmenopausal women by norethisterone.炔诺酮预防绝经后妇女骨矿物质流失
Obstet Gynecol. 1985 Dec;66(6):789-92.
3
Sex steroids and bone mass. A study of changes about the time of menopause.性类固醇与骨量。一项关于绝经前后变化的研究。
J Clin Invest. 1987 Nov;80(5):1261-9. doi: 10.1172/JCI113201.
4
Evidence of estrogen receptors in normal human osteoblast-like cells.正常人成骨样细胞中雌激素受体的证据。
Science. 1988 Jul 1;241(4861):84-6. doi: 10.1126/science.3388021.
5
Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations.从酶解释放的大鼠颅骨细胞群体中在体外形成的矿化骨结节。
Calcif Tissue Int. 1986 Mar;38(3):143-54. doi: 10.1007/BF02556874.
6
Uncoupling of bone formation and resorption by combined oestrogen and progestagen therapy in postmenopausal osteoporosis.雌激素和孕激素联合治疗绝经后骨质疏松症时骨形成与骨吸收的解偶联
Lancet. 1985 Oct 12;2(8459):800-1. doi: 10.1016/s0140-6736(85)90794-9.
7
17 Beta-estradiol and continuous norethisterone: a unique treatment for established osteoporosis in elderly women.17β-雌二醇与炔诺酮连续用药：老年女性确诊骨质疏松症的独特治疗方法。
J Clin Endocrinol Metab. 1990 Oct;71(4):836-41. doi: 10.1210/jcem-71-4-836.
8
Stimulatory effects of estrogen and progesterone on proliferation and differentiation of normal human osteoblast-like cells in vitro.雌激素和孕激素对正常人成骨样细胞体外增殖和分化的刺激作用。
Biochem Biophys Res Commun. 1992 Jul 15;186(1):54-60. doi: 10.1016/s0006-291x(05)80774-0.