Determination of the Heart-to-Mediastinum Ratio of I-MIBG Uptake Using Dual-Isotope (I-MIBG/Tc-Tetrofosmin) Multipinhole Cadmium-Zinc-Telluride SPECT in Patients with Heart Failure.

The aim of this retrospective study was to compare the heart-to-mediastinum ratio (HMR) of I-metaiodobenzylguanidine (I-MIBG) uptake obtained using a multipinhole cadmium-zinc-telluride (CZT) camera with that obtained using conventional planar imaging. Forty consecutive heart failure patients underwent planar acquisition 4 h after I-MIBG injection (191 ± 41 [mean ± SD] MBq). To localize the heart using the CZT camera, Tc-tetrofosmin (358 ± 177 MBq) was administered and dual-isotope acquisition was performed. The HMRs were calculated with conventional planar imaging (HMR), with anterior reprojection images using the CZT camera (HMR), and with transaxial reconstructed images using the CZT camera (HMR). In a phantom study, we estimated a linear model fitting the CZT camera data to the planar data, and we applied it to provide corrected CZT camera-determined HMRs in patients (cHMR and cHMR). Thirty-four men and 6 women (71 ± 9 y old) with ischemic (22 patients) and nonischemic (18 patients) heart failure completed the study. For 22 of the 40 patients (55%), the New York Heart Association classification was class II and the ejection fraction was 35% ± 9%. HMR (1.12 ± 0.19) and HMR (1.35 ± 0.34) were lower than HMR (1.44 ± 0.14) ( < 0.0001 and < 0.01, respectively). cHMR (1.54 ± 0.09) and cHMR (1.45 ± 0.14) were significantly different ( < 0.0001). Lin concordance correlation and Bland-Altman analysis demonstrated an almost perfect concordance and a high agreement between HMR and cHMR ( was not significant) but not between HMR and cHMR ( < 0.0001). This study demonstrated that determination of the late HMR of cardiac I-MIBG uptake using dual-isotope (I and Tc) acquisition on a multipinhole CZT camera was feasible in patients with heart failure. However, this determination should be performed using transaxial reconstructed images and linear correction based on phantom data acquisitions.