ω-3 脂肪酸的摄入有助于年轻的日本女性群体髋部的骨密度。
Intake of omega-3 fatty acids contributes to bone mineral density at the hip in a younger Japanese female population.
机构信息
Public Health Research Foundation, 1-1-7 Nishiwaseda, Shinjuku-ku, Tokyo, 169-0051, Japan.
Clinical Medical Research Center, International University of Health and Welfare, Women's Medical Center, Sanno Medical Center, 8-5-35 Akasaka, Minato-ku, Tokyo, 107-0052, Japan.
出版信息
Osteoporos Int. 2017 Oct;28(10):2887-2891. doi: 10.1007/s00198-017-4128-7. Epub 2017 Jun 23.
UNLABELLED
This study investigated the relationships between intakes of polyunsaturated fatty acids, omega-3 fatty acids, and omega-6 fatty acids and bone mineral density in Japanese women aged 19 to 25 years. Intakes of omega-3 fatty acids (n-3) were positively associated with peak bone mass at the hip.
INTRODUCTION
Lifestyle factors such as physical activity and nutrition intake are known to optimize the peak bone mass (PBM). Recently, intake of polyunsaturated fatty acids (PUFAs) has been reported to contribute to bone metabolism. In this study, the relationships of intakes of n-3 and omega-6 (n-6) fatty acids with PBM were evaluated in Japanese female subjects.
METHODS
A total of 275 healthy female subjects (19-25 years) having PBM were enrolled, and lumbar and total hip bone mineral density (BMD) and bone metabolic parameters were measured. Dietary intakes of total energy, total n-3 fatty acids, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and total n-6 fatty acids were assessed by a self-administered questionnaire. Physical activity information was also assessed.
RESULTS
The mean ± SD age was 20.6 ± 1.4 years, and BMI was 21.2 ± 2.7 kg/m. BMI and serum bone alkaline phosphatase contributed significantly to lumbar BMD on multiple regression analysis. Intake of n-3 fatty acids and physical activity were also significantly related to total hip BMD. Using EPA or DHA instead of total n-3 fatty acids in the model did not result in a significant result.
CONCLUSION
Adequate total n-3 fatty acid intake may help maximize PBM at the hip.
本研究旨在探讨日本 19 至 25 岁女性多不饱和脂肪酸、ω-3 脂肪酸和 ω-6 脂肪酸摄入量与骨密度的关系。ω-3 脂肪酸（n-3）的摄入量与髋部峰值骨量呈正相关。
引言
生活方式因素，如体育活动和营养摄入，已知可优化峰值骨量（PBM）。最近，有研究报道多不饱和脂肪酸（PUFA）的摄入有助于骨代谢。在这项研究中，评估了日本女性受试者中 n-3 和 ω-6（n-6）脂肪酸摄入量与 PBM 的关系。
方法
共纳入 275 名具有 PBM 的健康女性受试者（19-25 岁），测量腰椎和全髋骨密度（BMD）和骨代谢参数。通过自我管理问卷评估总能量、总 n-3 脂肪酸、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和总 n-6 脂肪酸的摄入量。还评估了体育活动信息。
结果
平均年龄±标准差为 20.6±1.4 岁，BMI 为 21.2±2.7kg/m2。BMI 和血清骨碱性磷酸酶在多元回归分析中对腰椎 BMD 有显著贡献。n-3 脂肪酸的摄入量和体力活动与全髋骨密度也有显著相关性。在模型中用 EPA 或 DHA 代替总 n-3 脂肪酸并没有导致显著结果。
结论
足够的总 n-3 脂肪酸摄入可能有助于最大限度地提高髋部的 PBM。
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