Tian Li-Wen, Zhang Zhen, Long Hai-Lan, Zhang Ying-Jun
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Nat Prod Bioprospect. 2017 Aug;7(4):283-298. doi: 10.1007/s13659-017-0139-5. Epub 2017 Jun 23.
The Smilax species, widely distributed in tropical region of the world and the warm areas of East Asia and North America, are extensively used as folk medicine to treat inflammatory disorders. Chemical investigation on Smilax species showed they are rich sources of steroidal saponins with diversified structure types, including spirostane, isospirostane, furostane, pregnane, and cholestane. This review mainly summarizes the steroidal saponins (1-104) reported from the genus Smilax between 1967 and 2016, and their biological activities. The relationship between structures of steroidal saponins and related biological activities were briefly discussed.
菝葜属植物广泛分布于世界热带地区以及东亚和北美的温暖地区，被广泛用作民间药物来治疗炎症性疾病。对菝葜属植物的化学研究表明，它们是结构类型多样的甾体皂苷的丰富来源，包括螺旋甾烷、异螺旋甾烷、呋甾烷、孕甾烷和胆甾烷。本综述主要总结了1967年至2016年间从菝葜属植物中报道的甾体皂苷（1 - 104）及其生物活性。并简要讨论了甾体皂苷结构与相关生物活性之间的关系。
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