School of Life Sciences, Shanghai University, Shanghai, 200444, People's Republic of China.
Mol Cell Biochem. 2017 Dec;436(1-2):79-86. doi: 10.1007/s11010-017-3080-3. Epub 2017 Jun 23.
Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis. The metabolism of glioma is following the Warburg effect. Previous researches have shown that GLUT1, as a glucose transporter carrier, affected the Warburg effect, but the molecular mechanism is not very clear. CREB1 (cAMP responsive element-binding protein1) is involved in various biological processes, and relevant studies confirmed that CREB1 protein regulated the expression of GLUT1, thus mediating glucose transport in cells. Our experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.
脑胶质瘤起源于脑内的胶质细胞，约占颅内肿瘤的 45%。脑胶质瘤的特征是浸润性生长，正常脑组织与脑胶质瘤组织之间没有明显的界限，因此很难完全切除，预后最差。脑胶质瘤的代谢遵循瓦博格效应。以前的研究表明，GLUT1 作为葡萄糖转运载体，影响瓦博格效应，但分子机制尚不清楚。CREB1（cAMP 反应元件结合蛋白 1）参与各种生物过程，相关研究证实 CREB1 蛋白调节 GLUT1 的表达，从而介导细胞内的葡萄糖转运。我们的实验主要揭示了 CREB1 可以通过调节 GLUT1 的表达来影响脑胶质瘤细胞中的葡萄糖转运，从而控制脑胶质瘤的代谢，影响脑胶质瘤的进展。
