Gibson Tracey N, McNaughton Dawn P, Hanchard Barrie
Jamaica Cancer Registry, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica.
Cancer Causes Control. 2017 Nov;28(11):1219-1225. doi: 10.1007/s10552-017-0916-9. Epub 2017 Jun 23.
To determine the histological distribution and trends in incidence of sinonasal malignancies in Jamaica.
Cases of all sinonasal malignancies diagnosed between 1973 and 2007 were extracted from the archives of the Jamaica Cancer Registry. Data recorded for each case included age at diagnosis, sex, year of diagnosis, topography, and histology. Data were used to calculate frequencies, age-specific incidence rates, and age-standardized incidence rates (ASRs). Linear regression analysis was used to determine significance of trends in incidence rates; p values of ≤0.05 were significant.
Sinonasal malignancies were commoner in males (male: female ratio, 1.1:1), and the median ages were 62 (males) and 66 years (females). Most were located in either the maxillary sinus (61.3%) or nasal cavity (24.3%). The commonest histological types were squamous cell carcinoma (SCC) (55.9%) and non-Hodgkin's lymphoma (17.1%), which were predominantly of T-cell immunophenotype, in both the nasal cavity and sinuses. There was no documentation in registry data regarding separation into NK/T and peripheral T-subtypes. The ASRs in males and females were consistently less than 1.5 per 100,000 per year. In males, there was a significant decrease in SCC ASR (p = 0.014) over time.
The age, gender, and anatomical and histological distribution patterns of sinonasal malignancies in Jamaica are similar to those reported internationally, and the low ASRs are in keeping with previous global reports. Broader local immunohistochemistry panels are warranted for further delineation of sinonasal T-cell lymphomas. Investigation into factors contributing to the decreasing incidence of sinonasal SCC is also required.
确定牙买加鼻窦恶性肿瘤的组织学分布及发病率趋势。
从牙买加癌症登记处档案中提取1973年至2007年间诊断的所有鼻窦恶性肿瘤病例。记录的每个病例的数据包括诊断时的年龄、性别、诊断年份、部位及组织学类型。数据用于计算频率、年龄别发病率及年龄标准化发病率（ASR）。采用线性回归分析确定发病率趋势的显著性；p值≤0.05具有显著性。
鼻窦恶性肿瘤在男性中更为常见（男：女比例为1.1：1），中位年龄男性为62岁，女性为66岁。大多数位于上颌窦（61.3%）或鼻腔（24.3%）。最常见的组织学类型为鳞状细胞癌（SCC）（55.9%）和非霍奇金淋巴瘤（17.1%），在鼻腔和鼻窦中主要为T细胞免疫表型。登记数据中没有关于分为NK/T和外周T亚型的记录。男性和女性的ASR每年始终低于每10万人1.5例。在男性中，SCC的ASR随时间显著下降（p = 0.014）。
牙买加鼻窦恶性肿瘤的年龄、性别、解剖及组织学分布模式与国际报道相似，低ASR与先前的全球报告一致。需要更广泛的局部免疫组化面板来进一步明确鼻窦T细胞淋巴瘤。还需要调查导致鼻窦SCC发病率下降的因素。
