Wang Etienne C E, Christiano Angela M
Columbia University Medical Centre, Russ Berrie Medical Pavilion, New York City, NY, USA.
Adv Ther. 2017 Jul;34(7):1586-1593. doi: 10.1007/s12325-017-0540-9. Epub 2017 Jun 23.
Recent genetic and preclinical studies have increased our understanding of the immunopathogenesis of alopecia areata (AA). This has allowed expedited development of targeted therapies for the treatment of AA, and a paradigm shift in our approach and understanding of autoimmunity and the hair follicle. The synergy between preclinical studies, animal models, and translational studies has led to unprecedented advances in the treatment options for AA, ultimately benefiting patients who have had little recourse. In this review, we summarize the scientific field of contemporary AA research, and look forward to potential new technologies and developments.
最近的遗传学和临床前研究增进了我们对斑秃（AA）免疫发病机制的理解。这使得针对AA治疗的靶向疗法得以加速发展，也使我们在自身免疫和毛囊的研究方法及理解上发生了范式转变。临床前研究、动物模型和转化研究之间的协同作用，已在AA治疗方案方面取得了前所未有的进展，最终使那些几乎无计可施的患者受益。在本综述中，我们总结了当代AA研究的科学领域，并展望潜在的新技术和新进展。
