Moftah Nayera H, El-Barbary Rasha A H, Rashed Laila, Said Marwa
Dermatology and Venereology Department, Faculty of Medicine for Girls, Al Azhar University, 3 El-Sherkah El-Porsaeedeya, Ard Elgolf, Heliopolis, Cairo, 11361, Egypt.
Biochemistry Department, Cairo University, Cairo, Egypt.
Arch Dermatol Res. 2016 Aug;308(6):415-21. doi: 10.1007/s00403-016-1652-9. Epub 2016 May 3.
Alopecia areata incognita (AAI) is a type of diffuse hair fall with no confirmatory diagnostic test. The UL16 binding protein-3 (ULBP3) is ligands for natural-killer group 2, member D (NKG2D) receptor. It is a key regulator of both innate and adaptive immune responses. In the normal hair follicle, ULBP3 is turned off. However, different studies reported its high level in alopecia areata (AA). Therefore, this study was done to evaluate ULBP3 in AAI in comparison with telogen effluvium (TE), female pattern hair loss (FPHL), and normal hair. Biopsy specimens from 36 females suffering from AAI, 15 with FPHL, nine with TE, and ten healthy female controls were subjected to the immunogenetic detection of ULBP3 levels by real-time polymerase chain reaction (PCR). A high statistically significant increase in ULBP3 level in AAI patient group compared with FPHL, TE, and normal hair was detected. ULBP3 levels were positively correlated with the age and duration of the disease. Accordingly, ULBP3 may act as a confirmatory test for AAI. ULBP3 may be implicated in the disease pathogenesis, progression, and chronicity, and AAI may be a subtype of AA.
隐匿性斑秃（AAI）是一种无确诊诊断测试的弥漫性脱发类型。UL16结合蛋白3（ULBP3）是自然杀伤细胞2型D成员（NKG2D）受体的配体。它是先天性和适应性免疫反应的关键调节因子。在正常毛囊中，ULBP3处于关闭状态。然而，不同的研究报道其在斑秃（AA）中水平较高。因此，本研究旨在评估AAI中ULBP3与休止期脱发（TE）、女性型脱发（FPHL）及正常头发相比的情况。对36例AAI女性患者、15例FPHL女性患者、9例TE患者及10名健康女性对照的活检标本进行实时聚合酶链反应（PCR）免疫遗传学检测，以测定ULBP3水平。与FPHL、TE及正常头发相比，AAI患者组的ULBP3水平在统计学上有高度显著升高。ULBP3水平与疾病的年龄和病程呈正相关。因此，ULBP3可能作为AAI的确诊测试。ULBP3可能与疾病的发病机制、进展及慢性化有关，且AAI可能是AA的一个亚型。
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