Chen Lin, Zhang Donghui, Zhang Wenyue, Zhu Yuxiao, Hou Min, Yang Bingya, Xu Zhipeng, Ji Minjun, Wu Guanling
Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.
Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing, Jiangsu, China.
Parasit Vectors. 2017 Jun 24;10(1):306. doi: 10.1186/s13071-017-2250-1.
The involvement of CD8T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined.
In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 mice infected with S. japonicum. We found alleviated liver granulomatous inflammation in Batf3 mice with schistosomiasis japonica could not be attributed to the difference in schistosome egg or worm burden. The stronger Tc1 cell responses observed in Batf3 mice suggested that the deletion of Batf3 resulted in more activation of CD8T cells unexpectedly during the natural infection of schistosomes. We detected a small amount of CD8α DCs in the spleen of Batf3 mice at 9w post-infection. This small amount of newly generated CD8α DCs might contribute to enhanced activation of CD8T cells via cross-presentation and activation which then attenuate hepatic pathological damage found in Batf3 mice.
Our study provides evidence that Batf3 is associated with the immunoregulation of the liver granuloma formation, which may confer a new options for schistosomiasis treatment.
CD8T细胞在血吸虫病中的作用越来越受到重视，但其潜在机制尚未明确。
在本研究中，我们发现缺失Batf3可减轻感染日本血吸虫的Batf3-/-小鼠的肝脏损伤。我们发现，日本血吸虫病Batf3-/-小鼠肝脏肉芽肿性炎症减轻并非归因于血吸虫虫卵或虫体负荷的差异。在Batf3-/-小鼠中观察到更强的Tc1细胞反应，这表明在血吸虫自然感染过程中，Batf3的缺失意外地导致了CD8T细胞的更多激活。我们在感染后9周检测到Batf3-/-小鼠脾脏中有少量CD8α DCs。这少量新产生的CD8α DCs可能通过交叉呈递和激活促进CD8T细胞的增强激活，进而减轻Batf3-/-小鼠的肝脏病理损伤。
我们的研究提供了证据表明Batf3与肝脏肉芽肿形成的免疫调节有关，这可能为血吸虫病治疗提供新的选择。
