Özkurt Zübeyde Nur, Batmaz Leyla, Yeğin Zeynep Arzu, İlhan Çiğdem
Gazi University, Faculty of Medicine, Department of Hematology and Stem Cell Transplantation Unit, Turkey.
Gazi University, Faculty of Medicine, Department of Internal Medicine, Turkey.
Transfus Apher Sci. 2017 Jun;56(3):470-473. doi: 10.1016/j.transci.2017.05.021. Epub 2017 Jun 3.
Infused CD34 cell count has a significant impact on transplant outcome. In this retrospective study, we aimed to analyze the impact of donor iron parameters on peripheral blood stem cell (PBSC) collection. A total of 303 related donors were included in the study. The mobilization regimen, recombinant G-CSF, was given for four consecutive days. A CD34 cell count below 2×10/kg was defined as mobilization failure which was demonstrated in 23 donors (7.6%). Mobilization failure was more frequent in female donors than male donors (13.7% vs 3.4%). Body mass index, mean corpuscular volume, hemoglobin and ferritin levels were found to be lower in donors with mobilization failure. Body mass index was significantly correlated with PBSC count on the 4th day of G-CSF. Body mass index, male gender, mean corpuscular volume and ferritin levels had significant impact on PBSC count. Although PBSC count was found to be similar between female and male donors, female gender was shown to have an adverse impact on PBSC collection, which may be attributed to lower body weight and concurrent iron deficiency.
输注的CD34细胞计数对移植结果有显著影响。在这项回顾性研究中，我们旨在分析供体铁参数对外周血干细胞（PBSC）采集的影响。共有303名相关供体纳入本研究。动员方案为连续四天给予重组G-CSF。CD34细胞计数低于2×10/kg被定义为动员失败，23名供体（7.6%）出现了这种情况。女性供体的动员失败比男性供体更常见（13.7%对3.4%）。发现动员失败的供体的体重指数、平均红细胞体积、血红蛋白和铁蛋白水平较低。体重指数与G-CSF第4天的PBSC计数显著相关。体重指数、男性性别、平均红细胞体积和铁蛋白水平对PBSC计数有显著影响。虽然发现女性和男性供体之间的PBSC计数相似，但女性性别对PBSC采集有不利影响，这可能归因于体重较低和同时存在的缺铁情况。
