Zheng Yu, Xue Jing, Gao Yang, Dong Lei, Dou Jun-Rong, Ma Wei
Department of Biomedical Engineering, School of Electronics and Information Engineering, Tianjin Polytechnic University, No. 399 Binshui Road, Xiqing District, Tianjin, China.
School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
J Membr Biol. 2017 Oct;250(5):433-440. doi: 10.1007/s00232-017-9967-9. Epub 2017 Jun 24.
Electric fields (EF) can induce some physiological or biological effects in neural tissues, which have been explored in many applications such as electroporation. The key to understand the possible underlying mechanisms of such effects tend to be the induced transmembrane potential. Although transmembrane potentials have already been the subject of many theoretical studies, most previous works concerning this topic are mainly focused on the situations of isolated cells. In previous studies, cells are often considered to be three-compartment models with different electroconductivities in different regions (the three compartments are often intracellular regions, membrane, and extracellular regions). In the present paper, we utilize a finite element method (FSM) (with the help of COMSOL) to calculate the induced transmembrane potential by the applied EF for a model of two neurons, which may have significant difference on electroporation.
电场（EF）可在神经组织中诱发一些生理或生物学效应，这些效应已在诸如电穿孔等许多应用中得到探索。理解此类效应可能的潜在机制的关键往往在于诱发的跨膜电位。尽管跨膜电位已经是许多理论研究的主题，但此前关于该主题的大多数工作主要集中在孤立细胞的情况。在先前的研究中，细胞通常被视为在不同区域具有不同电导率的三室模型（这三个室通常是细胞内区域、细胞膜和细胞外区域）。在本文中，我们利用有限元方法（FSM）（借助COMSOL）来计算施加的电场作用于两个神经元模型时诱发的跨膜电位，这两个神经元在电穿孔方面可能存在显著差异。
