Feng Shuying, Wang Chen, Hu Shu, Wu Qiongya, Li Aifang
Medical College, Henan University of Science and Technology, No. 263 Kaiyuan Avenue, Luoyang, 471023, Henan, China.
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, Henan, China.
Arch Virol. 2017 Oct;162(10):2923-2936. doi: 10.1007/s00705-017-3450-x. Epub 2017 Jun 24.
White spot syndrome virus (WSSV) has been extensively investigated since the white spot disease outbreak in shrimp in 1990. These investigations have mainly focused on determining the function of viral structural proteins, and on utilizing the envelope proteins as subunit vaccines to protect the host. These studies have shown that a WSSV vaccine can be a practical and effective approach for controlling WSSV infection. The development of such a vaccine has become an intense focus of research in the field. This research has resulted in significant progress in the development of WSSV vaccines. However, because of the progress of this work, periodic summaries are needed to facilitate further research on the development of effective WSSV vaccines. This paper provides a comprehensive summary on the status of WSSV vaccines with regard to the following aspects: subunit vaccines, inactivated whole virus vaccines, DNA vaccines, protective antibodies, and the application of RNAi technology. Current limitations in this area of research are also described, as well as prospects for the development and application of improved WSSV vaccines in the future, and for investigating other important aquatic diseases.
自1990年对虾爆发白斑病以来，白斑综合征病毒（WSSV）已得到广泛研究。这些研究主要集中在确定病毒结构蛋白的功能，以及利用包膜蛋白作为亚单位疫苗来保护宿主。这些研究表明，WSSV疫苗可能是控制WSSV感染的一种切实有效的方法。开发这样一种疫苗已成为该领域研究的一个热点。这项研究在WSSV疫苗的开发方面取得了重大进展。然而，由于这项工作的进展，需要定期进行总结，以促进对有效WSSV疫苗开发的进一步研究。本文从以下几个方面对WSSV疫苗的现状进行了全面总结：亚单位疫苗、灭活全病毒疫苗、DNA疫苗、保护性抗体以及RNAi技术的应用。还描述了该研究领域目前的局限性，以及未来改进WSSV疫苗的开发和应用前景，以及研究其他重要水生疾病的前景。
