Veckenstedt A, Güttner J, Béládi I
Acta Virol. 1985 May;29(3):216-24.
The influence of increasing doses of various potentially antiviral agents on Mengo virus-and Sindbis virus-infected mice was assessed determining death rates and histologic lesions. All drugs given in abundance showed dose-dependent decrease of antiviral activity following the maximum protective effects in either animal model. From the toxicological point of view the antiviral agents in question could be classified into two groups. High doses of tilorone hydrochloride or 10-carboxymethyl-9-acridanone produced toxic effects in both uninfected and virus-infected animals. In contrast, high doses of quercetin, double-stranded ribonucleic acid (dsRNA), 1-ethylisatin-S-n-butylisothiosemicarbazone or Norakin induced no obvious drug-mediated histologic alterations either in uninfected or in virus-infected individuals, but exerted a decreased protection in virus-infected animals. It is suggested that high doses of the compounds of second group adversely affect early host defence in both Mengo virus and Sindbis virus-infected mice.
通过测定死亡率和组织学损伤，评估了不同剂量的各种潜在抗病毒药物对感染门戈病毒和辛德毕斯病毒小鼠的影响。在两种动物模型中，所有大量给药的药物在达到最大保护作用后，其抗病毒活性均呈剂量依赖性下降。从毒理学角度来看，所讨论的抗病毒药物可分为两类。高剂量的盐酸替洛隆或10-羧甲基-9-吖啶酮在未感染和病毒感染的动物中均产生毒性作用。相比之下，高剂量的槲皮素、双链核糖核酸（dsRNA）、1-乙基异吲哚酮-S-正丁基异硫代半卡巴腙或诺拉金在未感染或病毒感染的个体中均未引起明显的药物介导的组织学改变，但在病毒感染的动物中保护作用减弱。提示高剂量的第二组化合物对感染门戈病毒和辛德毕斯病毒的小鼠的早期宿主防御有不利影响。
