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来自养殖软珊瑚短指花软珊瑚的具有生物活性的新型睡茄内酯

Bioactive new withanolides from the cultured soft coral Sinularia brassica.

作者信息

Huang Chiung-Yao, Ahmed Atallah F, Su Jui-Hsin, Sung Ping-Jyun, Hwang Tsong-Long, Chiang Pei-Lun, Dai Chang-Feng, Liaw Chih-Chuang, Sheu Jyh-Horng

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

出版信息

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3267-3271. doi: 10.1016/j.bmcl.2017.06.029. Epub 2017 Jun 10.

DOI:10.1016/j.bmcl.2017.06.029
PMID:28648460
Abstract

Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H-L (1-5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1-5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1-6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.

摘要

对养殖软珊瑚短指花软珊瑚（Sinularia brassica）的乙酸乙酯提取物进行持续研究，得到了5个新的维A醇类化合物，即短指花软珊瑚醇H-L（1-5）。通过光谱分析阐明了这些新化合物的结构。测定了新化合物1-5和已知化合物短指花软珊瑚醇A（6）对一组有限癌细胞系增殖的细胞毒性。通过测量化合物1-6抑制人中性粒细胞中N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸/细胞松弛素B（fMLP/CB）诱导的超氧阴离子生成和弹性蛋白酶释放的能力，评估了它们的抗炎活性。

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