Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt.
Mar Drugs. 2022 Oct 14;20(10):640. doi: 10.3390/md20100640.
In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically active metabolites, allowing them to study their biological activity in many pharmacological assays and even produce sufficient quantities for clinical trials. In this review, we summarize 201 secondary metabolites that have been identified from cultured soft corals in the era from 2002 to September 2022. Various types of diterpenes (eunicellins, cembranes, spatanes, norcembranes, briaranes, and aquarianes), as well as biscembranes, sterols, and quinones were discovered and subjected to bioactivity investigations in 53 different studies. We also introduce a more in-depth discussion of the potential biological effects (anti-cancer, anti-inflammatory, and anti-microbial) and the mechanisms of action of the identified secondary metabolites. We hope this review will shed light on the untapped potential applications of aquaculture to produce valuable secondary metabolites to tackle current and emerging health conditions.
近几十年来，软珊瑚的水产养殖技术在条件和生产力方面取得了显著的进步。研究人员已经能够获得更多数量的软珊瑚，从而获得更多具有生物活性的代谢物，使他们能够在许多药理学检测中研究它们的生物活性，甚至生产出足够数量的药物进行临床试验。在这篇综述中，我们总结了 201 种从 2002 年到 2022 年 9 月养殖的软珊瑚中鉴定出的次生代谢产物。在 53 项不同的研究中发现并研究了各种类型的二萜（海扇烯、海鞘素、石烷、诺海鞘素、布里亚烷和 Aquariane），以及双海鞘素、甾醇和醌。我们还介绍了对鉴定出的次生代谢产物的潜在生物学效应（抗癌、抗炎和抗微生物）和作用机制的更深入讨论。我们希望这篇综述能够揭示水产养殖生产有价值的次生代谢产物以应对当前和新出现的健康状况的未开发潜力。
