Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mar Drugs. 2018 Mar 13;16(3):93. doi: 10.3390/md16030093.
Three new polyoxygenated steroids, michosterols A-C (-), and four known compounds (-) were isolated from the ethyl acetate (EtOAc) extract of the soft coral , collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and comparison of the nuclear magnetic resonance (NMR) data with related steroids. The cytotoxicity of compounds - against the proliferation of a limited panel of cancer cell lines was assayed. Compound was found to display moderate cytotoxicity against adenocarcinomic human alveolar basal epithelial (A549) cancer cells. It also exhibited potent anti-inflammatory activity by suppressing superoxide anion generation and elastase release in -formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-stimulated human neutrophils. Furthermore, could effectively inhibit elastase release, as well.
从台东县海域采集的软珊瑚中分离得到三个新的多氧化甾体化合物米考甾醇 A-C（-）和四个已知化合物（-）。根据光谱分析和与相关甾体的核磁共振（NMR）数据比较，确定了新化合物的结构。对化合物-对一组有限的癌细胞系增殖的细胞毒性进行了测定。发现化合物对腺癌细胞（A549）具有中等的细胞毒性。它还通过抑制甲酰基-甲硫氨酸-亮氨酸-苯丙氨酸/细胞松弛素 B（fMLP/CB）刺激的人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放，表现出很强的抗炎活性。此外，还能有效抑制弹性蛋白酶的释放。
