Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, Box 2462, 3001 Heverlee, Belgium.
Nat Rev Microbiol. 2017 Sep;15(9):517-530. doi: 10.1038/nrmicro.2017.61. Epub 2017 Jun 26.
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant pathogen Pseudomonas syringae. The bacteriophages that infect Pseudomonas spp. mirror the widespread and diverse nature of their hosts. Therefore, Pseudomonas spp. and their phages are an ideal system to study the molecular mechanisms that govern virus-host interactions. Furthermore, phages are principal catalysts of host evolution and diversity, which directly affects the ecological roles of environmental and pathogenic Pseudomonas spp. Understanding these interactions not only provides novel insights into phage biology but also advances the development of phage therapy, phage-derived antimicrobial strategies and innovative biotechnological tools that may be derived from phage-bacteria interactions.
假单胞菌属中的物种在多样化的生态环境中繁衍生息，其中包括一些重要的病原体，如人类病原体铜绿假单胞菌和植物病原体丁香假单胞菌。感染假单胞菌属的噬菌体反映了其宿主广泛而多样的性质。因此，假单胞菌属及其噬菌体是研究控制病毒-宿主相互作用的分子机制的理想系统。此外，噬菌体是宿主进化和多样性的主要催化剂，这直接影响到环境和致病性假单胞菌属的生态角色。了解这些相互作用不仅为噬菌体生物学提供了新的见解，也为噬菌体治疗、噬菌体衍生的抗菌策略以及可能源于噬菌体-细菌相互作用的创新生物技术工具的发展提供了帮助。
