Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 21, bus 2462, B-3001 Leuven, Belgium.
Future Microbiol. 2010 Jul;5(7):1041-55. doi: 10.2217/fmb.10.66.
Pseudomonas species and their bacteriophages have been studied intensely since the beginning of the 20th century, due to their ubiquitous nature, and medical and ecological importance. Here, we summarize recent molecular research performed on Pseudomonas phages by reviewing findings on individual phage genera. While large phage collections are stored and characterized worldwide, the limits of their genomic diversity are becoming more and more apparent. Although this article emphasizes the biological background and molecular characteristics of these phages, special attention is given to emerging studies in coevolutionary and in therapeutic settings.
假单胞菌及其噬菌体自 20 世纪初以来一直受到广泛关注,这主要是由于它们无处不在的特性,以及在医学和生态学方面的重要性。在这里,我们通过回顾单个噬菌体属的研究结果,对近年来有关假单胞菌噬菌体的分子研究进行了总结。虽然世界各地都储存和鉴定了大量的噬菌体,但它们的基因组多样性的局限性越来越明显。尽管本文强调了这些噬菌体的生物学背景和分子特征,但特别关注了它们在协同进化和治疗方面的新兴研究。