Hwang Misun, De Jong Robert M, Herman Stephan, Boss Renee, Riggs Becky, Tekes-Brady Aylin, Spevak Melissa, Poretti Andrea, Soares Bruno P, Bailey Christopher R, Dunn Emily, Shin Samuel S, Shrot Shai, Huisman Thierry A G M
Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland, USA.
J Ultrasound Med. 2017 Nov;36(11):2379-2386. doi: 10.1002/jum.14289. Epub 2017 Jun 26.
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.
对脑灌注进行敏感、特异且安全的床旁评估是新生儿缺氧缺血性损伤早期诊断、治疗及提高生存率的关键。超声造影成像（US）是一种新型成像技术，静脉注射的含气微泡因声阻抗不匹配产生增强的超声回声。本文描述了2例新生儿缺氧缺血性损伤的超声造影成像以及开发定量超声造影技术以更好地描述灌注异常的未来方向。还强调了研究新生儿缺氧缺血性损伤时脑灌注时间演变的重要性。
