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脑内去甲肾上腺素和5-羟色胺含量的研究——I. 正常及冷暴露情况

Studies of contents of norepinephrine and 5-hydroxytryptamine in brain--I. Normal and cold exposure.

作者信息

Aly M S, Mohamed M I, Rahman T A, Moustafa S

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):155-8. doi: 10.1016/0742-8413(85)90223-3.

DOI:10.1016/0742-8413(85)90223-3
PMID:2865055
Abstract

The levels of NE and 5-HT were determined in different brain regions of the field rat and the guinea-pig under normal conditions and following cold exposure at 10 degrees C. Under normal conditions NE was found to be mainly accumulated in the midbrain while 5-HT exhibited its highest value in the pons plus medulla of both animals. Cold exposure of the field rat caused a general increase in NE concentrations while a general decrease occurred in the brain regions of the guinea-pig. 5-HT mostly decreased in the two animals. These changes in the amine levels could be related directly to the animal's response to cold.

摘要

在正常条件下以及在10摄氏度冷暴露后,测定了田鼠和豚鼠不同脑区中去甲肾上腺素(NE)和5-羟色胺(5-HT)的水平。在正常条件下,发现NE主要积聚在中脑,而5-HT在两种动物的脑桥加延髓中含量最高。田鼠冷暴露导致NE浓度普遍升高,而豚鼠脑区中NE浓度普遍降低。两种动物的5-HT大多降低。胺水平的这些变化可能与动物对寒冷的反应直接相关。

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