IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Oct;64(10):1429-1438. doi: 10.1109/TUFFC.2017.2719942. Epub 2017 Jun 26.
A method is explored for increasing the sensitivity of power-Doppler imaging without contrast enhancement. We acquire 1-10 s of echo signals and arrange it into a 3-D spatiotemporal data array. An eigenfilter developed to preserve all three dimensions of the array yields power estimates for blood flow and perfusion that are well separated from tissue clutter. This method is applied at high frequency (24-MHz pulses) to a murine model of an ischemic hindlimb. We demonstrate enhancements to tissue perfusion maps in normal and ischemic tissues. The method can be applied to data from any ultrasonic instrument that provides beamformed RF echo data.
探讨了一种无需对比增强即可提高功率多普勒成像灵敏度的方法。我们采集 1-10 秒的回波信号，并将其排列成三维时空数据阵列。开发的特征滤波器可保留阵列的所有三个维度，从而为血流和灌注提供准确的功率估计，与组织杂波明显区分。该方法应用于高频（24MHz 脉冲）的缺血性后肢鼠模型。我们在正常和缺血组织中展示了组织灌注图的增强效果。该方法可应用于任何提供波束形成射频回波数据的超声仪器的数据。
