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海德堡离子束治疗中心用于质子、氦离子、碳离子和氧离子束的蒙特卡罗治疗计划工具在水中的剂量验证。

Dosimetric verification in water of a Monte Carlo treatment planning tool for proton, helium, carbon and oxygen ion beams at the Heidelberg Ion Beam Therapy Center.

作者信息

Tessonnier T, Böhlen T T, Ceruti F, Ferrari A, Sala P, Brons S, Haberer T, Debus J, Parodi K, Mairani A

机构信息

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany. Department of Medical Physics, Ludwig-Maximilians-Universität München, Munich, Germany.

出版信息

Phys Med Biol. 2017 Jul 31;62(16):6579-6594. doi: 10.1088/1361-6560/aa7be4.

Abstract

The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. We present in this study a dosimetric validation of a FLUKA-based Monte Carlo treatment planning tool (MCTP) for protons, helium, carbon and oxygen ions for spread-out Bragg peaks in water. The comparisons between the ions show the dosimetric advantages of helium and heavier ion beams in terms of their distal and lateral fall-offs with respect to protons, reducing the lateral size of the region receiving 50% of the planned dose up to 12 mm. However, carbon and oxygen ions showed significant doses beyond the target due to the higher fragmentation tail compared to lighter ions (p and He), up to 25%. The Monte Carlo predictions were found to be in excellent geometrical agreement with the measurements, with deviations below 1 mm for all parameters investigated such as target and lateral size as well as distal fall-offs. Measured and simulated absolute dose values agreed within about 2.5% on the overall dose distributions. The MCTP tool, which supports the usage of multiple state-of-the-art relative biological effectiveness models, will provide a solid engine for treatment planning comparisons at HIT.

摘要

粒子治疗中“新”离子种类的引入需要通过对其剂量学特性进行全面评估,并与临床使用的质子和碳离子束进行治疗计划比较来支持。除了后两种离子外,海德堡离子束治疗中心(HIT)预计将在不久的将来使用氦离子束和氧离子束,作为改善临床疗效的潜在手段。我们在本研究中对基于FLUKA的蒙特卡罗治疗计划工具(MCTP)进行了剂量学验证,该工具用于质子、氦离子、碳离子和氧离子在水中的扩展布拉格峰。离子之间的比较显示了氦离子束和较重离子束在远端和侧向剂量跌落方面相对于质子的剂量学优势,将接受计划剂量50%的区域的侧向尺寸减小了12毫米。然而,与较轻离子(质子和氦离子)相比,碳离子和氧离子由于更高的碎片尾部,在靶区之外显示出显著剂量,高达25%。发现蒙特卡罗预测与测量结果在几何上具有极好的一致性,对于所有研究参数,如靶区和侧向尺寸以及远端剂量跌落,偏差均低于1毫米。测量和模拟的绝对剂量值在总体剂量分布上的一致性约为2.5%。支持使用多种最新相对生物效应模型的MCTP工具将为HIT的治疗计划比较提供坚实的引擎。

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