Tu Xiao-Jing, Hwang Wen-Juh, Hsu Shih-Pin, Ma Hui-Ing
Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan.
Department of Neurology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan.
Health Qual Life Outcomes. 2017 Apr 18;15(1):75. doi: 10.1186/s12955-017-0642-8.
The responsiveness of a measurement instrument is important for understanding its ability to detect changes in the progression of a disease. We examined and compared the internal and external responsiveness of the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson's Disease Questionnaire (PDQ-39) in patients with Parkinson's Disease (PD).
Seventy-four patients with PD were evaluated using the SF-36 and PDQ-39 at baseline and again after one year. In addition, their motor signs, motor difficulties of daily living, and depressive symptoms were assessed as external criteria. The internal responsiveness was examined using effect size, standardized response mean, and the Wilcoxon signed rank test. The external responsiveness was examined using receiver operating characteristic curves, correlation analyses, and regression models.
Both instruments were partially sensitive to changes during the 1-year follow-up and able to discriminate between patients with improved versus deteriorated motor signs. In addition, both were similarly responsive to changes in the motor difficulties of daily living; the SF-36 appeared to be more sensitive than the PDQ-39 to changes in depressive symptoms.
The SF-36 and the PDQ-39 were acceptably internally and externally responsive during the 1-year follow-up.
测量工具的反应性对于理解其检测疾病进展变化的能力很重要。我们检查并比较了帕金森病（PD）患者中36项简短健康调查（SF - 36）和39项帕金森病问卷（PDQ - 39）的内部和外部反应性。
74例PD患者在基线时以及1年后再次使用SF - 36和PDQ - 39进行评估。此外，评估他们的运动体征、日常生活中的运动困难和抑郁症状作为外部标准。使用效应量、标准化反应均值和Wilcoxon符号秩检验检查内部反应性。使用受试者工作特征曲线、相关分析和回归模型检查外部反应性。
在1年的随访期间，两种工具对变化均部分敏感，并且能够区分运动体征改善与恶化的患者。此外，两者对日常生活中运动困难的变化反应相似；SF - 36似乎比PDQ - 39对抑郁症状的变化更敏感。
在1年的随访期间，SF - 36和PDQ - 39在内部和外部反应性方面均可接受。
