Chien Chu-Yen, Hung Yi-Jen, Shieh Yi-Shing, Hsieh Chang-Hsun, Lu Chieh-Hua, Lin Fu-Huang, Su Sheng-Chiang, Lee Chien-Hsing
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
PLoS One. 2017 Jun 26;12(6):e0179963. doi: 10.1371/journal.pone.0179963. eCollection 2017.
BACKGROUND/OBJECTIVES: Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study were to investigate the associations of serum PDIA4 with the metabolic syndrome (MetS) and its components in Chinese adults.
SUBJECTS/METHODS: A total of 669 adults (399 men and 270 women) were recruited. Serum PDIA4 concentrations and biochemical variables were recorded. Insulin sensitivity and β-cell function were examined by homeostasis model assessment. MetS was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asia Pacific.
The participants with MetS had significantly higher serum PDIA4 levels than those without MetS (P<0.001). After adjustments, the individuals with the highest PDIA4 tertile were associated with a higher risk of MetS than those with the lowest tertile (OR = 4.83, 95% CI: 2.71-8.60). The concentration of PDIA4 showed a stepwise increase with the components of MetS (P<0.001 for trend). The individuals with the highest PDIA4 tertile were significantly associated with waist circumference (OR = 2.41, 95% CI 1.34-4.32), blood pressure (OR = 2.71, 95% CI 1.57-4.67), fasting glucose concentration (OR = 3.17, 95% CI 1.80-5.57), and serum triglycerides (OR = 4.12, 95% CI 2.30-7.37) than those with the lowest tertile. At cutoff point of 15.24 ng/ml, the diagnostic sensitivity and specificity of PDIA4 for the metabolic syndrome were 67 and 72%, respectively, in male patients and 60 and 78%, respectively, in female patients. Finally, the result showed that PDIA4 had a significantly higher area under the curve compared with blood pressure to detect MetS using receiver operating characteristic analysis.
Serum PDIA4 concentrations are closely associated to MetS and its components in Chinese adults.
背景/目的：蛋白质二硫键异构酶（PDI）家族成员是内质网特异性蛋白，参与包括神经退行性疾病、癌症和肥胖症在内的多种疾病的发病机制。然而，PDIA4在人体中的代谢作用仍不清楚。本研究旨在探讨中国成年人血清PDIA4与代谢综合征（MetS）及其组分之间的关联。
对象/方法：共招募了669名成年人（399名男性和270名女性）。记录血清PDIA4浓度和生化变量。通过稳态模型评估检查胰岛素敏感性和β细胞功能。根据修改后的亚太地区国家胆固醇教育计划成人治疗小组III标准定义代谢综合征。
患有代谢综合征的参与者血清PDIA4水平显著高于未患代谢综合征的参与者（P<0.001）。调整后，与最低三分位数者相比，最高三分位数的PDIA4个体患代谢综合征的风险更高（OR = 4.83，95%CI：2.71 - 8.60）。PDIA4浓度随代谢综合征的组分呈逐步升高（趋势P<0.001）。与最低三分位数者相比，最高三分位数的PDIA4个体与腰围（OR = 2.41，95%CI 1.34 - 4.32）、血压（OR = 2.71，95%CI 1.57 - 4.67）、空腹血糖浓度（OR = 3.17，95%CI 1.80 - 5.57）和血清甘油三酯（OR = 4.12，95%CI 2.30 - 7.37）显著相关。在截断点为15.24 ng/ml时，PDIA4对男性患者代谢综合征的诊断敏感性和特异性分别为67%和72%，对女性患者分别为60%和78%。最后，结果显示，使用受试者工作特征分析检测代谢综合征时，PDIA4的曲线下面积显著高于血压。
中国成年人血清PDIA4浓度与代谢综合征及其组分密切相关。
