Loeschke K, Abb J, Farack U M, Wiebecke B
Hepatogastroenterology. 1985 Aug;32(4):178-80.
A 26-year-old patient developed HBsAg-, HBeAg-positive chronic active hepatitis arising from an acute infection 6 months earlier. Treatment with adenine arabinoside (Ara-A), 15 mg/kg/day administered as overnight infusions for three weeks, resulted in clinical and complete biochemical remission with normalisation of aminotransferases, loss of HBsAg, HBeAg and DNA polymerase, and appearance of Anti-HBs during follow-up for 9 months. Treatment of chronic hepatitis B infection using Ara-A for several weeks may be especially effective when initiated early in the course of the disease.
一名26岁患者在6个月前急性感染后发展为乙肝表面抗原（HBsAg）阴性、乙肝e抗原（HBeAg）阳性的慢性活动性肝炎。使用阿糖腺苷（Ara - A）进行治疗，剂量为15毫克/千克/天，通过夜间输注给药，持续三周，结果在9个月的随访期间实现了临床和完全生化缓解，转氨酶恢复正常，HBsAg、HBeAg和DNA聚合酶消失，并且出现了乙肝表面抗体（Anti - HBs）。在疾病早期开始使用阿糖腺苷治疗慢性乙型肝炎感染数周可能特别有效。
