Perrillo R, Campbell C, Wellinghoff W, Gelb L
Am J Gastroenterol. 1982 Jul;77(7):445-9.
The purpose of this study was to examine the association of circulating viral markers with ongoing liver disease in chronic hepatitis B virus infection. Hepatitis B e antigen (HBeAg) was significantly more likely to be associated with abnormal alanine aminotransferase (ALT) activity than was anti-HBe in a group of 102 HBsAg carriers (p less than 0.0001). Within this group, 57 carriers were analyzed for HBeAg, DNA polymerase, and hepatitis B surface antigen (HBsAg) titer, and the relation of each with abnormal ALT was determined. Both HBeAg and elevated DNA polymerase were much more likely to reflect abnormal ALT (p less than 0.00001 and 0.0006, respectively) than did HBsAg titer. Unlike previous studies, higher titers of HBsAg would not be demonstrated in healthy carriers when compared to HBsAg carriers with chronic elevation of ALT; nor were differences in titer appreciated between chronic active and chronic persistent hepatitis. The potential significance of these findings is discussed.
本研究的目的是检测慢性乙型肝炎病毒感染中循环病毒标志物与持续性肝病之间的关联。在一组102名HBsAg携带者中，乙肝e抗原（HBeAg）相比于乙肝e抗体（抗-HBe），与丙氨酸氨基转移酶（ALT）活性异常的相关性显著更高（p小于0.0001）。在该组中，对57名携带者进行了HBeAg、DNA聚合酶和乙肝表面抗原（HBsAg）滴度分析，并确定了每一项与ALT异常之间的关系。与HBsAg滴度相比，HBeAg和升高的DNA聚合酶更有可能反映ALT异常（分别为p小于0.00001和0.0006）。与以往研究不同的是，与ALT慢性升高的HBsAg携带者相比，健康携带者中未显示出更高滴度的HBsAg；慢性活动性肝炎和慢性持续性肝炎之间也未发现滴度差异。文中讨论了这些发现的潜在意义。
