Gratuze Maud, Planel Emmanuel
Faculté de Médecine, Département de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada; Centre de Recherche du CHU de Québec, Québec, QC, Canada.
J Exp Med. 2017 Aug 7;214(8):2171-2173. doi: 10.1084/jem.20170979. Epub 2017 Jun 26.
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function.