• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

没食子酸乙酯部位通过 JNK/Akt 通路改善 TMT 诱导的小鼠脑神经元丢失和认知障碍。

Ethyl Acetate Fraction from Persimmon () Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice.

机构信息

Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea.

Division of Special Forest Products, National Institute of Forest Science, Suwon 16631, Korea.

出版信息

Int J Mol Sci. 2018 May 17;19(5):1499. doi: 10.3390/ijms19051499.

DOI:10.3390/ijms19051499
PMID:29772805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5983595/
Abstract

This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon () (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. EFDK had high antioxidant activities and neuroprotective effects in HT22 cells. EFDK ameliorated behavioral and memory deficits in Y-maze, passive avoidance and Morris water maze tests. Also, EFDK restored the antioxidant system by regulating malondialdehyde (MDA), superoxide dismutase (SOD) and reduced gluthathione (GSH), and the cholinergic system by controlling the acetylcholine (ACh) level and acetylcholinesterase (AChE) activity and expression. EFDK enhanced mitochondrial function by regulating reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), and adenosine triphosphate (ATP). Ultimately, EFDK regulated the c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) pathway and apoptotic pathway by suppressing the expression of tumor necrosis factor-alpha (TNF-α), phosphorylated insulin receptor substrate 1 (IRS-1pSer), phosphorylated JNK (p-JNK), phosphorylated tau (p-tau), phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells (p-NF-κB), Bcl-2-associated X protein (BAX) and cytosolic cytochrome c, and increasing the expression of phosphorylated Akt (p-Akt) and mitochondrial cytochrome c. This study suggested that EFDK had antioxidant activity and a neuroprotective effect, and ameliorated cognitive abnormalities in TMT-induced mice by regulating the JNK/Akt and apoptotic pathway.

摘要

本研究旨在评估柿（）乙酸乙酯部位（EFDK）对 H₂O₂诱导的海马 HT22 细胞和三甲基锡氯化物（TMT）诱导的癌症研究所（ICR）小鼠的抗氧化能力和保护作用。EFDK 在 HT22 细胞中具有较高的抗氧化活性和神经保护作用。EFDK 改善了 Y 迷宫、被动回避和 Morris 水迷宫测试中的行为和记忆缺陷。此外，EFDK 通过调节丙二醛（MDA）、超氧化物歧化酶（SOD）和还原型谷胱甘肽（GSH），以及通过控制乙酰胆碱（ACh）水平和乙酰胆碱酯酶（AChE）活性和表达来调节胆碱能系统，来恢复抗氧化系统。EFDK 通过调节活性氧（ROS）产生、线粒体膜电位（MMP）和三磷酸腺苷（ATP）来增强线粒体功能。最终，EFDK 通过抑制肿瘤坏死因子-α（TNF-α）、胰岛素受体底物 1（IRS-1pSer）磷酸化、c-Jun N 末端激酶（JNK）磷酸化、磷酸化 tau（p-tau）、磷酸化核因子 kappa-轻链增强子的表达来调节 JNK/蛋白激酶 B（Akt）通路和凋亡通路活化 B 细胞（p-NF-κB）、Bcl-2 相关 X 蛋白（BAX）和细胞质细胞色素 c，并增加磷酸化 Akt（p-Akt）和线粒体细胞色素 c 的表达。本研究表明，EFDK 具有抗氧化活性和神经保护作用，并通过调节 JNK/Akt 和凋亡通路改善 TMT 诱导的小鼠认知异常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/dfe76549108f/ijms-19-01499-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/0bb1d8660b9b/ijms-19-01499-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/7b341b166274/ijms-19-01499-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/3c4e9771df67/ijms-19-01499-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/a21cf927db29/ijms-19-01499-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/f7b69f9faffc/ijms-19-01499-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/2149ed57839b/ijms-19-01499-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/1a7b0a17de37/ijms-19-01499-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/c23c12a4c8a5/ijms-19-01499-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/0ba7e5f90590/ijms-19-01499-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/600801783e55/ijms-19-01499-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/dfe76549108f/ijms-19-01499-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/0bb1d8660b9b/ijms-19-01499-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/7b341b166274/ijms-19-01499-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/3c4e9771df67/ijms-19-01499-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/a21cf927db29/ijms-19-01499-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/f7b69f9faffc/ijms-19-01499-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/2149ed57839b/ijms-19-01499-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/1a7b0a17de37/ijms-19-01499-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/c23c12a4c8a5/ijms-19-01499-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/0ba7e5f90590/ijms-19-01499-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/600801783e55/ijms-19-01499-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79a4/5983595/dfe76549108f/ijms-19-01499-g011.jpg

相似文献

1
Ethyl Acetate Fraction from Persimmon () Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice.没食子酸乙酯部位通过 JNK/Akt 通路改善 TMT 诱导的小鼠脑神经元丢失和认知障碍。
Int J Mol Sci. 2018 May 17;19(5):1499. doi: 10.3390/ijms19051499.
2
Chronic Alcohol Exposure Induced Neuroapoptosis: Diminishing Effect of Ethyl Acetate Fraction from .慢性酒精暴露诱导的神经细胞凋亡：.乙酸乙酯部位的抑制作用。
Oxid Med Cell Longev. 2019 May 9;2019:7849876. doi: 10.1155/2019/7849876. eCollection 2019.
3
Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice.未成熟柿子通过 Tau 病理学抑制 ICR 小鼠淀粉样 β (Aβ) 介导的认知功能障碍。
Curr Issues Mol Biol. 2021 Jun 21;43(1):405-422. doi: 10.3390/cimb43010033.
4
Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice.辽东楤木通过JNK信号通路对高脂饮食诱导的糖尿病小鼠认知功能障碍的抗遗忘作用
Behav Brain Res. 2016 Oct 1;312:39-54. doi: 10.1016/j.bbr.2016.06.013. Epub 2016 Jun 8.
5
Green Tea Seed Oil Suppressed Aβ-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway.绿茶籽油通过与 Aβ 相关的 Akt 通路抑制 Aβ 诱导的行为和认知障碍。
Int J Mol Sci. 2019 Apr 15;20(8):1865. doi: 10.3390/ijms20081865.
6
DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway.新型双胆碱酯酶抑制剂DL0410通过Akt/JNK信号通路保护小鼠大脑免受Aβ诱导的神经元损伤。
Acta Pharmacol Sin. 2016 Nov;37(11):1401-1412. doi: 10.1038/aps.2016.87. Epub 2016 Aug 8.
7
The effect of ethyl acetate extract from persimmon leaves on Alzheimer's disease and its underlying mechanism.柿叶乙酸乙酯提取物对阿尔茨海默病的影响及其潜在机制。
Phytomedicine. 2016 Jun 15;23(7):694-704. doi: 10.1016/j.phymed.2016.03.009. Epub 2016 Apr 11.
8
Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid.3,5-二咖啡酰奎宁酸对三甲基锡诱导的学习和记忆缺陷的逆转作用
Oxid Med Cell Longev. 2016;2016:6981595. doi: 10.1155/2016/6981595. Epub 2016 Dec 25.
9
Neuroprotective effect of -derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.- 多糖对过氧化氢诱导的神经元 HT22 细胞损伤的神经保护作用。
Biosci Biotechnol Biochem. 2020 May;84(5):1001-1012. doi: 10.1080/09168451.2020.1715201. Epub 2020 Jan 21.
10
Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice.鸡冠花乙酸乙酯提取物可减轻小鼠糖尿病相关认知功能障碍。
Food Res Int. 2018 Mar;105:589-598. doi: 10.1016/j.foodres.2017.11.063. Epub 2017 Nov 26.

引用本文的文献

1
Green tea enriched with catechins prevents particulate matter exposure-induced cardiovascular cytotoxicity via regulation of ferroptosis in BALB/c mice.富含儿茶素的绿茶通过调节BALB/c小鼠的铁死亡来预防颗粒物暴露诱导的心血管细胞毒性。
Food Sci Biotechnol. 2025 Feb 27;34(10):2255-2267. doi: 10.1007/s10068-025-01831-0. eCollection 2025 Jun.
2
Feasibility study of PET/CT for the detection and localization of nervous system damage caused by trimethyltin chloride.正电子发射断层显像/X线计算机体层成像（PET/CT）用于检测和定位三甲基氯化锡所致神经系统损伤的可行性研究
Sci Rep. 2025 Jan 8;15(1):1353. doi: 10.1038/s41598-024-82473-w.
3

本文引用的文献

1
NF-κB signaling in inflammation.NF-κB 信号转导与炎症
Signal Transduct Target Ther. 2017;2:17023-. doi: 10.1038/sigtrans.2017.23. Epub 2017 Jul 14.
2
Flavonoid-rich ethanol extract from the leaves of Diospyros kaki attenuates cognitive deficits, amyloid-beta production, oxidative stress, and neuroinflammation in APP/PS1 transgenic mice.柿树叶中富含黄酮类化合物的乙醇提取物可减轻APP/PS1转基因小鼠的认知缺陷、β淀粉样蛋白生成、氧化应激和神经炎症。
Brain Res. 2018 Jan 1;1678:85-93. doi: 10.1016/j.brainres.2017.10.001. Epub 2017 Oct 14.
3
Regulation of brain insulin signaling: A new function for tau.
Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway.
亚硒酸钠通过RNS/NF-κB/NLRP3途径拮抗三甲基锡诱导的鸡肝毒性肝炎。
Poult Sci. 2025 Jan;104(1):104449. doi: 10.1016/j.psj.2024.104449. Epub 2024 Nov 8.
4
Leaves Alleviate Cognitive Dysfunction in Dextran Sulfate Sodium (DSS)-Induced Colitis Mice through Regulating JNK/TLR4 Signaling Pathway.叶片通过调节 JNK/TLR4 信号通路减轻葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠的认知功能障碍。
Int J Mol Sci. 2024 Apr 5;25(7):4063. doi: 10.3390/ijms25074063.
5
Anti-Amnesia-like Effect of Extract by Improving Apoptosis and Neuroinflammation on Trimethyltin-Induced ICR Mice.提取物通过改善三甲基锡诱导的ICR小鼠的细胞凋亡和神经炎症发挥抗失忆样作用。
Int J Mol Sci. 2023 Sep 14;24(18):14084. doi: 10.3390/ijms241814084.
6
Protective Effect of on PM-Induced Pulmonary Damage in BALB/c Mice via the TGF-β and NF-κB Pathway.通过TGF-β和NF-κB途径对PM诱导的BALB/c小鼠肺损伤的保护作用
Antioxidants (Basel). 2023 Apr 20;12(4):968. doi: 10.3390/antiox12040968.
7
Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice.未成熟柿子通过 Tau 病理学抑制 ICR 小鼠淀粉样 β (Aβ) 介导的认知功能障碍。
Curr Issues Mol Biol. 2021 Jun 21;43(1):405-422. doi: 10.3390/cimb43010033.
8
Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction.抹茶改善代谢失衡引起的认知功能障碍。
Oxid Med Cell Longev. 2020 Nov 28;2020:8882763. doi: 10.1155/2020/8882763. eCollection 2020.
9
History repeats itself: Role of characterizing flavors on nicotine use and abuse.历史总是重演：味道特征在尼古丁使用和滥用中的作用。
Neuropharmacology. 2020 Oct 15;177:108162. doi: 10.1016/j.neuropharm.2020.108162. Epub 2020 Jun 1.
10
(L.) Schott Fruits Increase Stress Resistance and Exert Antioxidant Properties in and Mouse Models.（L.）Schott 水果可增强 和 模型的应激抵抗能力并发挥抗氧化特性。
Molecules. 2019 Jul 19;24(14):2633. doi: 10.3390/molecules24142633.
大脑胰岛素信号传导的调节：tau蛋白的新功能。
J Exp Med. 2017 Aug 7;214(8):2171-2173. doi: 10.1084/jem.20170979. Epub 2017 Jun 26.
4
In vitro antioxidative and binding properties of phenolics in traditional, citrus and exotic fruits.传统水果、柑橘类水果和外来水果中酚类物质的体外抗氧化和结合特性。
Food Res Int. 2015 Aug;74:37-47. doi: 10.1016/j.foodres.2015.04.021. Epub 2015 Apr 20.
5
Vanillic acid attenuates Aβ-induced oxidative stress and cognitive impairment in mice.香草酸可减轻 Aβ诱导的小鼠氧化应激和认知障碍。
Sci Rep. 2017 Jan 18;7:40753. doi: 10.1038/srep40753.
6
Comparison of sensory and compositions of five selected persimmon cultivars (Diospyros kaki L.) and correlations between chemical components and processing characteristics.五个选定柿品种（柿属柿树）的感官和成分比较以及化学成分与加工特性之间的相关性。
J Food Sci Technol. 2016 Mar;53(3):1597-607. doi: 10.1007/s13197-015-2102-y. Epub 2015 Nov 10.
7
The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways.利拉鲁肽通过激活 PI3K/AKT 和 MAPK 通路对缺血诱导的细胞凋亡的神经保护作用。
Sci Rep. 2016 May 31;6:26859. doi: 10.1038/srep26859.
8
The effect of ethyl acetate extract from persimmon leaves on Alzheimer's disease and its underlying mechanism.柿叶乙酸乙酯提取物对阿尔茨海默病的影响及其潜在机制。
Phytomedicine. 2016 Jun 15;23(7):694-704. doi: 10.1016/j.phymed.2016.03.009. Epub 2016 Apr 11.
9
Persimmon (Diospyros kaki) fruit: hidden phytochemicals and health claims.柿子（柿属植物）果实：潜在的植物化学成分及健康宣称。
EXCLI J. 2015 May 4;14:542-61. doi: 10.17179/excli2015-159. eCollection 2015.
10
Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties.柿子（柿属植物）叶：传统用途、植物化学与药理特性综述
J Ethnopharmacol. 2015 Apr 2;163:229-40. doi: 10.1016/j.jep.2015.01.007. Epub 2015 Jan 28.